Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Int J Mol Sci. 2018 Jan 31;19(2):424. doi: 10.3390/ijms19020424.
Coronary artery disease (CAD) is one of the most common causes of death worldwide. In the last decade, significant advancements in CAD treatment have been made. The existing treatment is medical, surgical or a combination of both depending on the extent, severity and clinical presentation of CAD. The collaboration between different science disciplines such as biotechnology and tissue engineering has led to the development of novel therapeutic strategies such as stem cells, nanotechnology, robotic surgery and other advancements (3-D printing and drugs). These treatment modalities show promising effects in managing CAD and associated conditions. Research on stem cells focuses on studying the potential for cardiac regeneration, while nanotechnology research investigates nano-drug delivery and percutaneous coronary interventions including stent modifications and coatings. This article aims to provide an update on the literature (in vitro, translational, animal and clinical) related to these novel strategies and to elucidate the rationale behind their potential treatment of CAD. Through the extensive and continued efforts of researchers and clinicians worldwide, these novel strategies hold the promise to be effective alternatives to existing treatment modalities.
冠状动脉疾病 (CAD) 是全球最常见的死亡原因之一。在过去的十年中，CAD 的治疗取得了重大进展。现有的治疗方法是医学、手术或两者的结合，具体取决于 CAD 的程度、严重程度和临床表现。生物技术和组织工程等不同科学学科的合作，导致了新型治疗策略的发展，如干细胞、纳米技术、机器人手术和其他进展（3D 打印和药物）。这些治疗方式在管理 CAD 和相关疾病方面显示出有希望的效果。干细胞研究侧重于研究心脏再生的潜力，而纳米技术研究则研究纳米药物输送和经皮冠状动脉介入治疗，包括支架修改和涂层。本文旨在提供有关这些新型策略的文献（体外、转化、动物和临床）的最新信息，并阐明其治疗 CAD 的潜在原理。通过全球研究人员和临床医生的广泛而持续的努力，这些新型策略有望成为现有治疗方式的有效替代方法。
