Younis Mohammed, Elshahat Ahmed, Elhabbaa Gamal, Fareed Ahmed, Safe Ikram
J Craniofac Surg. 2014 Nov;25(6):2237-40. doi: 10.1097/SCS.0000000000001043.
Onlay bone grafts have a bad reputation of resorption with loss of contour and volume. Rigid fixation reduces the incidence of resorption but does not prevent it. Literature shows reduction of resorption by applying guided bone regeneration (GBR) barriers and platelet-rich plasma (PRP). Investigating the effect of combining them together to reduce resorption was the aim of this study. This study included 4 groups: control group, GBR group, PRP group, and GBR + PRP group. Twenty rabbits were used (40 mandibular halves). Onlay bone grafts were fixed by titanium miniscrews in all groups. Computed tomography scans of harvested mandibles after euthanasia allowed calculations of bone graft volume and density. Onlay bone graft volumes in all experimental groups were significantly higher than in the control group. Volume maintenance in the GBR group was significantly higher than in the PRP group. There was no significant difference in the volume of onlay bone grafts between the group of combined GBR + PRP and GBR alone. It was concluded that, to maintain the volume of onlay bone grafts, either GBR or PRP can be added. Combining them did not add any advantage over the GBR alone.
外置植骨术因骨吸收导致外形和体积丧失而声名不佳。坚固内固定可降低骨吸收的发生率，但无法完全防止。文献表明，应用引导骨再生（GBR）屏障和富血小板血浆（PRP）可减少骨吸收。本研究旨在探究将两者联合使用以减少骨吸收的效果。本研究共纳入4组：对照组、GBR组、PRP组和GBR + PRP组。使用了20只兔子（40个下颌骨半侧）。所有组均使用微型钛钉固定外置植骨。对安乐死后采集的下颌骨进行计算机断层扫描，以计算植骨的体积和密度。所有实验组的外置植骨体积均显著高于对照组。GBR组的体积维持率显著高于PRP组。联合使用GBR + PRP组与单独使用GBR组的外置植骨体积无显著差异。研究得出结论，为维持外置植骨的体积，可添加GBR或PRP。将两者联合使用相较于单独使用GBR并无额外优势。
