髓源性抑制细胞对肿瘤转移的调控
Regulation of tumor metastasis by myeloid-derived suppressor cells.
作者信息
Condamine Thomas, Ramachandran Indu, Youn Je-In, Gabrilovich Dmitry I
机构信息
The Wistar Institute, Philadelphia, Pennsylvania 19104; email:
出版信息
Annu Rev Med. 2015;66:97-110. doi: 10.1146/annurev-med-051013-052304. Epub 2014 Oct 9.
Abstract
Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one of the major immunological hallmarks of cancer. In recent years, it became clear that in addition to their immune-suppressive activity, myeloid-derived suppressor cells (MDSCs) influence tumor progression in a variety of ways. They are directly implicated in the promotion of tumor metastases by participating in the formation of premetastatic niches, promoting angiogenesis and tumor cell invasion. In this review, we discuss recent data describing various roles of MDSCs in the formation of tumor metastases.
摘要
具有强大免疫抑制活性的病理活化未成熟髓样细胞的积累是癌症的主要免疫特征之一。近年来，越来越清楚的是，髓源性抑制细胞（MDSC）除了具有免疫抑制活性外，还以多种方式影响肿瘤进展。它们通过参与前转移生态位的形成、促进血管生成和肿瘤细胞侵袭，直接参与促进肿瘤转移。在这篇综述中，我们讨论了描述MDSC在肿瘤转移形成中各种作用的最新数据。
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本文引用的文献
1
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J Immunol Res. 2014;2014:879897. doi: 10.1155/2014/879897. Epub 2014 Jan 29.
2
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer.肿瘤诱导的单核细胞来源的髓样抑制细胞中的 STAT3 激活增强了人胰腺癌细胞的干性和间充质特性。
Cancer Immunol Immunother. 2014 May;63(5):513-28. doi: 10.1007/s00262-014-1527-x. Epub 2014 Mar 21.
3
Transmembrane TNF-α promotes suppressive activities of myeloid-derived suppressor cells via TNFR2.跨膜 TNF-α 通过 TNFR2 促进髓源性抑制细胞的抑制活性。
J Immunol. 2014 Feb 1;192(3):1320-31. doi: 10.4049/jimmunol.1203195. Epub 2013 Dec 30.
4
Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.葡萄膜黑色素瘤发生转移患者的循环免疫细胞和 microRNA。
Mol Immunol. 2014 Apr;58(2):182-6. doi: 10.1016/j.molimm.2013.11.018. Epub 2013 Dec 25.
5
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Cancer Immunol Immunother. 2014 Mar;63(3):247-57. doi: 10.1007/s00262-013-1508-5. Epub 2013 Dec 20.
6
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Clin Cancer Res. 2014 Mar 15;20(6):1601-9. doi: 10.1158/1078-0432.CCR-13-2508. Epub 2013 Dec 9.
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Cancer Cell. 2013 Nov 11;24(5):631-44. doi: 10.1016/j.ccr.2013.10.009.
8
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9
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