Condamine Thomas, Ramachandran Indu, Youn Je-In, Gabrilovich Dmitry I
The Wistar Institute, Philadelphia, Pennsylvania 19104; email:
Annu Rev Med. 2015;66:97-110. doi: 10.1146/annurev-med-051013-052304. Epub 2014 Oct 9.
Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one of the major immunological hallmarks of cancer. In recent years, it became clear that in addition to their immune-suppressive activity, myeloid-derived suppressor cells (MDSCs) influence tumor progression in a variety of ways. They are directly implicated in the promotion of tumor metastases by participating in the formation of premetastatic niches, promoting angiogenesis and tumor cell invasion. In this review, we discuss recent data describing various roles of MDSCs in the formation of tumor metastases.
具有强大免疫抑制活性的病理活化未成熟髓样细胞的积累是癌症的主要免疫特征之一。近年来，越来越清楚的是，髓源性抑制细胞（MDSC）除了具有免疫抑制活性外，还以多种方式影响肿瘤进展。它们通过参与前转移生态位的形成、促进血管生成和肿瘤细胞侵袭，直接参与促进肿瘤转移。在这篇综述中，我们讨论了描述MDSC在肿瘤转移形成中各种作用的最新数据。
