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不孕不育与转基因食品之间的假设联系。

Hypothetical link between infertility and genetically modified food.

作者信息

Gao Mingxia, Li Bin, Yuan Wenzhen, Zhao Lihui, Zhang Xuehong

机构信息

Reproductive Medicine Hospital of the First Affiliated Hospital, Lanzhou University, Lanzhou, 730000, P. R. China..

出版信息

Recent Pat Food Nutr Agric. 2014;6(1):16-22. doi: 10.2174/2212798406666141024111228.

Abstract

It is speculated that genetically modified food (GMF)/genetically modified organism (GMO) is responsible for infertility development. The risk linked with a wide use of GMFs/GMOs offers the basic elements for social criticism. However, to date, it has not been justified whether the bad effects are directly resulted from products of genetic modifications or trans-genesis process. Extensive experience with the risk assessment of whole foods has been applied recently on the safety and nutritional testing of GMFs/GMOs. Investigations have tested the safety of GMFs including sub-acute, chronic, reproductive, multi-generation and carcinogenicity studies. We extrapolated the potential risks associated with GMFs/GMOs on reproduction, and analyzed the multi-aspect linked between infertility and GMFs/GMOs. It could be conjectured that GMFs/GMOs could be potential hazard on reproduction, linking to the development of infertility through influencing the endocrine metabolism, endometriosis. However, little evidence shows the impaction on embryo or reproductive related tumor due to the limited literatures, and needs further research. The article presents some related patents on GMFs/GMOs, and some methods for tracking GMOs.

摘要

据推测,转基因食品(GMF)/转基因生物(GMO)是导致不育症发展的原因。广泛使用GMF/GMO所带来的风险为社会批评提供了基本依据。然而,迄今为止,尚无法确定这些不良影响是否直接源于基因改造产品或转基因过程。最近,全食物风险评估的丰富经验已应用于GMF/GMO的安全性和营养测试。研究已经对GMF的安全性进行了测试,包括亚急性、慢性、生殖、多代和致癌性研究。我们推断了与GMF/GMO相关的生殖潜在风险,并分析了不育症与GMF/GMO之间的多方面联系。可以推测,GMF/GMO可能对生殖具有潜在危害,通过影响内分泌代谢、子宫内膜异位症与不育症的发展相关联。然而,由于文献有限,几乎没有证据表明其对胚胎或生殖相关肿瘤有影响,这需要进一步研究。本文介绍了一些关于GMF/GMO的相关专利,以及一些追踪转基因生物的方法。

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