Savage E M, McCormick D, McDonald S, Moore O, Stevenson M, Cairns A P
Department of Rheumatology, Musgrave Park Hospital, Stockman's Lane, Belfast, BT9 7JB, Northern Ireland, UK,
Rheumatol Int. 2015 May;35(5):887-90. doi: 10.1007/s00296-014-3161-5. Epub 2014 Oct 24.
To determine whether rheumatoid arthritis disease activity correlates with changing weather conditions. A longitudinal analysis of 133 patients attending the Department of Rheumatology, Musgrave Park Hospital, Belfast was performed. Participants had a diagnosis of rheumatoid arthritis and were receiving subcutaneous anti-TNF therapy (Adalimumab or Etanercept) for a period of >6 months. Data were collected at five time points. This included tender joint count, swollen joint count, patient visual analogue score (VAS), erythrocyte sedimentation rate, C-reactive protein, VAS, and DAS-28 (Disease Activity Score). Each weather factor (maximum, minimum temperature, pressure, rainfall, sunshine, humidity, and wind-speed) was analysed against each patients' DAS-28 score at five time points, using an analysis of covariance. A significant correlation was noted between low DAS-28 and increased hours of sunshine (p < 0.001). Sunny conditions were associated with a DAS-28 reduction of 0.037 (95 % CI -0.059, -0.016) p < 0.001. A significant correlation between humidity and DAS-28 was also noted (p = 0.016). Increased humidity was associated with an increased DAS-28 of 0.007 (95 % CI 0.001, 0.013) p = 0.016. Higher temperatures were associated with a non-significant decrease in DAS-28 (p = 0.16). In this study, rheumatoid arthritis disease activity (as measured by DAS-28) was significantly lower in both more sunny and less humid conditions.
为了确定类风湿性关节炎的疾病活动度是否与天气变化相关。对贝尔法斯特马斯格雷夫公园医院风湿病科的133例患者进行了纵向分析。参与者被诊断为类风湿性关节炎，并接受皮下抗TNF治疗（阿达木单抗或依那西普）超过6个月。在五个时间点收集数据。这包括压痛关节计数、肿胀关节计数、患者视觉模拟评分（VAS）、红细胞沉降率、C反应蛋白、VAS和DAS-28（疾病活动评分）。使用协方差分析，针对每个患者在五个时间点的DAS-28评分，分析每个天气因素（最高温度、最低温度、气压、降雨量、日照、湿度和风速）。发现低DAS-28与日照时长增加之间存在显著相关性（p<0.001）。晴天与DAS-28降低0.037相关（95%CI -0.059，-0.016）p<0.001。还发现湿度与DAS-28之间存在显著相关性（p = 0.016）。湿度增加与DAS-28增加0.007相关（95%CI 0.001，0.013）p = 0.016。较高温度与DAS-28的非显著降低相关（p = 0.16）。在本研究中，在日照较多和湿度较低的条件下，类风湿性关节炎的疾病活动度（以DAS-28衡量）显著较低。
