a Department of Pharmacognosy , School of Pharmacy, Second Military Medical University , Shanghai , China .
b Department of Pharmacognosy , School of Pharmacy, Third Military Medical University , Chongqing , China and.
Crit Rev Microbiol. 2016 May;42(3):454-73. doi: 10.3109/1040841X.2014.959892. Epub 2014 Oct 24.
Plant endophytic fungi have been recognized as an important and novel resource of natural bioactive products, especially in anticancer application. This review mainly deals with the research progress on the production of anticancer compounds by endophytic fungi between 1990 and 2013. Anticancer activity is generally associated with the cytotoxicity of the compounds present in the endophytic fungi. All strains of endophytes producing antitumor chemicals were classified taxonomically and the genera of Pestalotiopsis and Aspergillus as well as the taxol producing endophytes were focused on. Classification of endophytic fungi producing antitumor compounds has received more attention from mycologists, and it can also lead to the discovery of novel compounds with antitumor activity due to phylogenetic relationships. In this review, the structures of the anticancer compounds isolated from the newly reported endophytes between 2010 and 2013 are discussed including strategies for the efficient production of the desired compounds. The purpose of this review is to provide new directions in endophytic fungi research including integrated information relating to its anticancer compounds.
植物内生真菌已被公认为天然生物活性产物的一个重要且新颖的资源，尤其是在抗癌应用方面。本文主要综述了 1990 年至 2013 年间内生真菌产生抗癌化合物的研究进展。抗癌活性通常与内生真菌中存在的化合物的细胞毒性有关。所有产生抗肿瘤化学物质的内生菌菌株都根据分类学进行了分类，重点关注了拟盘多毛孢属和曲霉属以及紫杉醇产生内生菌。内生真菌产生抗肿瘤化合物的分类受到了真菌学家的更多关注，由于系统发育关系，它也可以导致具有抗癌活性的新型化合物的发现。在这篇综述中，讨论了 2010 年至 2013 年间新报道的内生菌分离得到的抗癌化合物的结构，包括有效生产所需化合物的策略。本文的目的是为内生真菌研究提供新的方向，包括与其抗癌化合物相关的综合信息。
