Fabbian Fabio, De Giorgi Alfredo, Monesi Marcello, Pala Marco, Tiseo Ruana, Misurati Elisa, Parisi Claudia, Volpi Riccardo, Graziani Roberto, Mikhailidis Dimitri P, Manfredini Roberto
Operative Unit of Clinica Medica, Department of Medical Sciences, University Hospital St. Anna, Ferrara, Italy
Operative Unit of Clinica Medica, Department of Medical Sciences, University Hospital St. Anna, Ferrara, Italy.
Diab Vasc Dis Res. 2015 Jan;12(1):46-52. doi: 10.1177/1479164114552656. Epub 2014 Oct 24.
We investigated the relationship between serum creatinine (SCr) and estimated glomerular filtration rate (eGFR), evaluated by different formulae, and all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) outpatients.
This observational cohort study considered 1365 T2DM outpatients, who had been followed up for a period of up to 11 years. eGFR was estimated using several equations.
Seventy subjects (5.1%) died after a follow-up of 9.8 ± 3 years. Univariate analysis showed that diagnosis of nephropathy (odds ratio (OR): 2.554, 95% confidence interval (CI): 1.616-4.038, p < 0.001) and microvascular complications (OR: 2.281, 95% CI: 1.449-3.593, p < 0.001) were associated with ACM. Receiving operating characteristic (ROC) curves showed that the areas under the curve for ACM were similar using the different eGFR equations. eGFR values were predictors of ACM, and the hazard ratios (HRs) of the different equations for eGFR estimation were similar.
In our cohort of T2DM outpatients, different eGFR equations perform similarly in predicting ACM, whereas SCr did not.
我们研究了2型糖尿病（T2DM）门诊患者中血清肌酐（SCr）与通过不同公式评估的估计肾小球滤过率（eGFR）以及全因死亡率（ACM）之间的关系。
这项观察性队列研究纳入了1365例T2DM门诊患者，随访时间长达11年。使用多个方程估算eGFR。
70名受试者（5.1%）在9.8±3年的随访后死亡。单因素分析显示，肾病诊断（比值比（OR）：2.554，95%置信区间（CI）：1.616 - 4.038，p<0.001）和微血管并发症（OR：2.281，95%CI：1.449 - 3.593，p<0.001）与ACM相关。受试者工作特征（ROC）曲线显示，使用不同的eGFR方程，ACM的曲线下面积相似。eGFR值是ACM的预测指标，不同eGFR估算方程的风险比（HR）相似。
在我们的T2DM门诊患者队列中，不同的eGFR方程在预测ACM方面表现相似，而SCr则不然。
