Xu Dongyun, Yi Wei, Chen Ying, Ma Lijun, Wang Jiejun, Yu Guanzhen
Department of Medical Oncology, Changzheng Hospital, Shanghai, 200070, China,
Med Oncol. 2014 Dec;31(12):261. doi: 10.1007/s12032-014-0261-8. Epub 2014 Oct 26.
Nonopioid Sigma1 receptor (Sig1R), which regulates various metabolism functions, has been implicated in cancers; yet, its role in hilar cholangiocarcinoma remains unclear. In the present study, we examined Sig1R expression in hilar cholangiocarcinoma (HC) tissues and explored its possible clinical values. Tissue microarray blocks containing 92 HC tissues and matched non-cancerous bile duct tissues were examined immunohistochemically for expression of Sig1R protein. Overexpression of Sig1R was found in 43 (46.7%) of the 92 primary tumor tissues. Overexpression of Sig1R was significantly associated with poor/undifferentiation (P = 0.011), tumor invasion (P = 0.001), lymph node metastasis (P = 0.047), and advanced disease stage (P = 0.024) of HC patients. Kaplan-Meier analysis showed that patients overexpressing Sig1R had an earlier recurrence and worse overall survival than those not overexpressing Sig1R. Cox regression analysis revealed that Sig1R was an independent factor to predict HC recurrence and prognosis of HC patients. Our results suggest that Sig1R is frequently activated in human HC tissue and overexpression of Sig1R might serve as a predictor for tumor recurrence and a prognostic biomarker for HC patients.
调节多种代谢功能的非阿片类西格玛1受体（Sig1R）与癌症有关；然而，其在肝门胆管癌中的作用仍不清楚。在本研究中，我们检测了肝门胆管癌（HC）组织中Sig1R的表达，并探讨了其可能的临床价值。采用免疫组织化学方法检测了包含92例HC组织及配对癌旁胆管组织的组织芯片块中Sig1R蛋白的表达。在92例原发性肿瘤组织中，43例（46.7%）发现Sig1R过表达。Sig1R过表达与HC患者的低分化/未分化（P = 0.011）、肿瘤侵袭（P = 0.001）、淋巴结转移（P = 0.047）及疾病晚期（P = 0.024）显著相关。Kaplan-Meier分析显示，Sig1R过表达的患者比未过表达Sig1R的患者复发更早，总生存期更差。Cox回归分析显示，Sig1R是预测HC复发及HC患者预后的独立因素。我们的结果表明，Sig1R在人HC组织中频繁激活，Sig1R过表达可能作为肿瘤复发的预测指标及HC患者的预后生物标志物。
