Wang D, Zhang H, Fang Z, Yu G
Department of General Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao, PR China.
Eur Surg Res. 2010;45(3-4):151-7. doi: 10.1159/000320237. Epub 2010 Oct 6.
Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and has been implicated in regulating inflammatory responses, cell proliferation and apoptosis. The evidence of its importance in carcinogenesis increased rapidly. However, the status of ANXA1 in hilar cholangiocarcinoma remains unclear. Here, we detected ANXA1 expression and determined its clinical significance in Chinese patients with hilar cholangiocarcinoma.
Tissue microarray blocks containing tumor specimens obtained from 61 patients were constructed. Expression of ANXA1 in these specimens was analyzed using immunohistochemical studies.
ANXA1 expression was observed in 27 cases (44.3%). Loss of ANXA1 expression was significantly associated with lymph node metastases and histopathologic grade. ANXA1 expression has a significant inverse correlation with recurrence and poor survival in univariate analyses.Multivariate analyses revealed that loss of ANXA1 expression was an independent predictor for future recurrence and overall survival in patients with cholangiocarcinoma.
Decreased expression of ANXA1 is a common event in human hilar cholangiocarcinoma and is significantly correlated with the poor outcome of patients with cholangiocarcinoma, suggesting a potential role of ANXA1 in cancer development and progression.
膜联蛋白A1（ANXA1）是一种钙和磷脂结合蛋白，与调节炎症反应、细胞增殖和凋亡有关。其在致癌过程中的重要性证据迅速增加。然而，ANXA1在肝门部胆管癌中的状态仍不清楚。在此，我们检测了中国肝门部胆管癌患者中ANXA1的表达，并确定了其临床意义。
构建包含61例患者肿瘤标本的组织芯片块。使用免疫组织化学研究分析这些标本中ANXA1的表达。
27例（44.3%）观察到ANXA1表达。ANXA1表达缺失与淋巴结转移和组织病理学分级显著相关。在单因素分析中，ANXA1表达与复发和不良生存呈显著负相关。多因素分析显示，ANXA1表达缺失是胆管癌患者未来复发和总生存的独立预测因素。
ANXA1表达降低在人类肝门部胆管癌中是常见事件，且与胆管癌患者的不良预后显著相关，提示ANXA1在癌症发生和发展中具有潜在作用。
