Wang Xianchun, Liang Songping
Sheng Wu Gong Cheng Xue Bao. 2014 Jul;30(7):1036-43.
Latrodectus tredecimguttatus (commonly known as black widow spiders) have toxins not only in their venom glands, but also in other parts of their body, in their eggs and even in the newborn spiderlings. The study on the toxins in venom and materials outside the venom glands of the spiders to elucidate their differences and similarities, evolutional relationship and biological functions is of important theoretical and applicable significance. The development of modern protein chemistry and proteomics techniques has provided efficient means for the study of protein and peptide toxins of L. tredecimguttatus. By using such techniques, the molecular base and action mechanism of the toxins can be revealed at the levels of both single purified proteins and omics. Up to now, although protein chemistry and proteomics study on L. tredecimguttatus toxins have achieved a certain progress, the relevant work particularly that on the toxins in the materials outside the venom glands has to be further deepened.
红斑寇蛛（俗称黑寡妇蜘蛛）不仅在其毒腺中含有毒素，在身体的其他部位、卵中甚至新生幼蛛体内也含有毒素。研究蜘蛛毒液和毒腺外物质中的毒素，以阐明它们的异同、进化关系及生物学功能，具有重要的理论和应用意义。现代蛋白质化学和蛋白质组学技术的发展为红斑寇蛛蛋白质和肽类毒素的研究提供了有效手段。利用这些技术，可以在单一纯化蛋白质和组学水平上揭示毒素的分子基础和作用机制。到目前为止，虽然对红斑寇蛛毒素的蛋白质化学和蛋白质组学研究取得了一定进展，但相关工作，特别是对毒腺外物质中毒素的研究仍需进一步深入。
