Colonna S M
G Ital Dermatol Venereol. 1989 Oct;124(10):479-84.
Our experience, accumulated over the past years, can confirm that topical azelaic acid, applied for long periods, does not give rise to toxic or allergic reactions. In this study we report the results obtained in the treatment of all types of acne (comedo or papulo-pustular acne). Azelaic acid cream showed a progressive and significant beneficial effect in all the patients who regularly followed the therapeutic program. Topically applied azelaic acid alone can yield clinically relevant improvement rates also in the treatment of inflammatory acne.
我们过去几年积累的经验可以证实,长期局部应用壬二酸不会引起毒性或过敏反应。在本研究中,我们报告了在治疗所有类型痤疮(粉刺型或丘疹脓疱型痤疮)中所获得的结果。壬二酸乳膏对所有定期遵循治疗方案的患者均显示出渐进且显著的有益效果。单独局部应用壬二酸在治疗炎性痤疮时也可产生具有临床意义的改善率。