Haasch G C, Gerstein H, Austin B P
J Endod. 1989 Jul;15(7):310-4. doi: 10.1016/S0099-2399(89)80053-6.
The effects of Adaptic and Avitene on bone healing were evaluated histologically. The studied materials were placed in osseous defects created in rat tibias with a #8 round bur in a slow-speed handpiece. The materials were left in situ for experimental periods of 7, 14, 28, 60, 90, and 120 days. Histological evaluation of specimens from each of these periods demonstrated that Avitene was resorbed and did not impede bone healing. Adaptic was not resorbed at the end of the longest experimental period, 120 days. This material caused a foreign body reaction characterized by encapsulation of the Adaptic by fibrous connective tissues. Both Adaptic and Avitene were satisfactory hemostatic agents. The results of this study suggest that Adaptic should be used only in those situations where complete retrieval of the material from surgical sites can be assured.
对Adaptic和Avitene对骨愈合的影响进行了组织学评估。将研究材料置于用低速手机的#8圆形钻头在大鼠胫骨上制造的骨缺损中。将材料原位留置7、14、28、60、90和120天的实验期。对这些时期中每个时期的标本进行组织学评估表明，Avitene被吸收且不妨碍骨愈合。在最长的实验期120天时，Adaptic未被吸收。这种材料引起了异物反应，其特征是Adaptic被纤维结缔组织包裹。Adaptic和Avitene都是令人满意的止血剂。本研究结果表明，Adaptic仅应在能够确保从手术部位完全取出材料的情况下使用。
