Genome3D：利用结构帮助用户理解他们的序列。
Genome3D: exploiting structure to help users understand their sequences.
作者信息
Lewis Tony E, Sillitoe Ian, Andreeva Antonina, Blundell Tom L, Buchan Daniel W A, Chothia Cyrus, Cozzetto Domenico, Dana José M, Filippis Ioannis, Gough Julian, Jones David T, Kelley Lawrence A, Kleywegt Gerard J, Minneci Federico, Mistry Jaina, Murzin Alexey G, Ochoa-Montaño Bernardo, Oates Matt E, Punta Marco, Rackham Owen J L, Stahlhacke Jonathan, Sternberg Michael J E, Velankar Sameer, Orengo Christine
机构信息
Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK.
Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK
出版信息
Nucleic Acids Res. 2015 Jan;43(Database issue):D382-6. doi: 10.1093/nar/gku973. Epub 2014 Oct 27.
Genome3D (http://www.genome3d.eu) is a collaborative resource that provides predicted domain annotations and structural models for key sequences. Since introducing Genome3D in a previous NAR paper, we have substantially extended and improved the resource. We have annotated representatives from Pfam families to improve coverage of diverse sequences and added a fast sequence search to the website to allow users to find Genome3D-annotated sequences similar to their own. We have improved and extended the Genome3D data, enlarging the source data set from three model organisms to 10, and adding VIVACE, a resource new to Genome3D. We have analysed and updated Genome3D's SCOP/CATH mapping. Finally, we have improved the superposition tools, which now give users a more powerful interface for investigating similarities and differences between structural models.
Genome3D（http://www.genome3d.eu）是一个合作资源库，为关键序列提供预测的结构域注释和结构模型。自上一篇发表于《核酸研究》的论文中介绍Genome3D以来，我们已对该资源进行了大幅扩展和改进。我们对来自 Pfam 家族的代表性序列进行了注释，以提高对不同序列的覆盖范围，并在网站上添加了快速序列搜索功能，以便用户找到与其自身序列相似的经Genome3D注释的序列。我们改进并扩展了Genome3D数据，将源数据集从三种模式生物扩大到10种，并添加了VIVACE，这是Genome3D中的一个新资源。我们分析并更新了Genome3D的SCOP/CATH映射。最后，我们改进了叠加工具，现在为用户提供了一个更强大的界面来研究结构模型之间的异同。
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