Zhao Yulei, Yang Xiaolong
Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Int J Cancer. 2015 Dec 15;137(12):2767-73. doi: 10.1002/ijc.29293. Epub 2014 Nov 8.
Chemotherapy is one of the major treatments for cancer patients. Although chemotherapeutic drugs can sometimes effectively suppress tumor growth in cancer patients, a significant proportion of patients are either intrinsically resistant or later develop resistance to primary chemotherapy, leading to disease relapse and patient mortality. The best way to conquer the resistance is the better understanding of the molecular network in cancer cells in response to drugs. Therefore, identification of signaling pathways and molecules involved in drug resistance is essential for successful treatment of cancers. The Hippo pathway is an emerging signaling pathway that plays important roles in tumorigenesis, stem cell self-renewal and differentiation, organ size control as well as many other biological processes. Therefore, exploring novel roles of the Hippo pathway in various biological functions has become one of the cutting-edge research areas in cancer and other biomedical research. Recently, we and others have provided new evidence that the Hippo pathway is involved in the resistance of different types of cancer cells to various chemotherapeutic drugs. In this review, we will discuss the specific roles of the Hippo pathway in chemotherapy, potential applications for studying this network in response to drugs as well as the future direction in identification of therapeutic targets.
化疗是癌症患者的主要治疗方法之一。尽管化疗药物有时能有效抑制癌症患者的肿瘤生长，但相当一部分患者要么天生耐药，要么后来对一线化疗产生耐药性，导致疾病复发和患者死亡。攻克耐药性的最佳方法是更好地了解癌细胞对药物反应的分子网络。因此，识别参与耐药性的信号通路和分子对于癌症的成功治疗至关重要。Hippo通路是一条新兴的信号通路，在肿瘤发生、干细胞自我更新和分化、器官大小控制以及许多其他生物学过程中发挥着重要作用。因此，探索Hippo通路在各种生物学功能中的新作用已成为癌症和其他生物医学研究的前沿研究领域之一。最近，我们和其他人提供了新的证据，表明Hippo通路参与了不同类型癌细胞对各种化疗药物的耐药性。在这篇综述中，我们将讨论Hippo通路在化疗中的具体作用、研究该网络对药物反应的潜在应用以及识别治疗靶点的未来方向。
