Kulkarni Aishwarya, Chang Matthew T, Vissers Joseph H A, Dey Anwesha, Harvey Kieran F
Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.
Departments of Discovery Oncology and Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.
Trends Cancer. 2020 Sep;6(9):781-796. doi: 10.1016/j.trecan.2020.04.004. Epub 2020 May 20.
The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Although Hippo has been linked to multiple aspects of cancer, its role in this disease is incompletely understood. Large-scale pan-cancer analyses of core Hippo pathway genes reveal that the pathway is mutated at a high frequency only in select human cancers, including malignant mesothelioma and meningioma. Hippo pathway deregulation is also enriched in squamous epithelial cancers. We discuss cancer-related functions of the Hippo pathway and potential explanations for the cancer-restricted mutation profile of core Hippo pathway genes. Greater understanding of Hippo pathway deregulation in cancers will be essential to guide the imminent use of Hippo-targeted therapies.
河马通路调节多种物种中的无数生物过程，是人类关键的癌症信号网络。尽管河马通路已与癌症的多个方面相关联，但其在这种疾病中的作用尚未完全了解。对核心河马通路基因的大规模泛癌分析表明，该通路仅在特定的人类癌症中高频突变，包括恶性间皮瘤和脑膜瘤。河马通路失调在鳞状上皮癌中也很常见。我们讨论了河马通路与癌症相关的功能，以及核心河马通路基因癌症限制性突变谱的潜在解释。更深入地了解癌症中河马通路的失调对于指导即将到来的河马靶向治疗的应用至关重要。
