J Cutan Med Surg. 2014 Nov;18(6):379-84. doi: 10.2310/7750.2014.13175.
A permanent, unpleasant atrophic leishmaniasis scar is a potentially disfiguring condition that causes social stigma with limited treatment choices. Fractionated carbon dioxide (CO2) laser resurfacing is expected to be a safe and effective treatment for leishmaniasis scars.
To assess the safety and efficacy of ablative fractional resurfacing (AFR) with a CO2 laser for facial leishmaniasis atrophic scars.
Eleven patients (five males, age 18-47 years) underwent the fractional CO2 laser procedure. The mean duration for scars was 18.3 years. Three to five treatment sessions with the fractional laser eCO2 (10,600 nm, Lutronic Corporation, Gyeonggi-do, Korea ) were performed for each patient, at 2-month intervals, under topical anesthesia. Two passes (with tip type 120, density 150 spots/cm2 in static mode, and peak power of 30 watts) were performed on each leishmaniasis scar. Pulse energies ranged between 100 and 140 mJ. Posttreatment improvements in texture, atrophy, and overall satisfaction with appearance were graded on a quartile scale 1 month after the second session and 3 months after the final session. Scar improvement was graded using a 4-point score with a maximum score of 20.
At the 3-month posttreatment follow-up, all subjects were rated as having at least 50% improvement in texture, atrophy, borders, and overall appearance of scars. The median score of improvement was 18 of 20 (range 11-19). Mild postinflammatory hyperpigmentation was the only adverse effect, observed in 18% (2 of 11) of subjects. After the procedure, moderate to severe erythema and edema typically resolved within 24 to 48 hours. No additional adverse effects were observed.
Fractional CO2 resurfacing represents a safe, effective, and well-tolerated potential treatment for atrophic facial leishmaniasis scars in ethnic skin.
永久性、令人不快的萎缩性利什曼病瘢痕是一种潜在的毁容性疾病,由于治疗选择有限,会导致社会耻辱。分馏二氧化碳(CO2)激光换肤术有望成为利什曼病瘢痕的安全有效治疗方法。
评估 CO2 激光消融性分馏(AFR)治疗面部利什曼病萎缩性瘢痕的安全性和疗效。
11 名患者(5 名男性,年龄 18-47 岁)接受了分馏 CO2 激光治疗。瘢痕的平均持续时间为 18.3 年。每位患者每 2 个月接受 3-5 次分馏激光 eCO2(10600nm,Lutronic 公司,京畿道,韩国)治疗,在局部麻醉下进行。在每个利什曼病瘢痕上进行两次通过(使用尖端类型 120,密度 150 点/cm2 静态模式,峰值功率 30 瓦)。脉冲能量在 100-140mJ 之间。第二次治疗后 1 个月和最后一次治疗后 3 个月,采用四分位评分法评估纹理、萎缩和整体外观满意度的改善情况。瘢痕改善程度采用 4 分制评分,最高得分为 20 分。
在治疗后 3 个月的随访中,所有患者的纹理、萎缩、边界和瘢痕整体外观均至少改善 50%。改善的中位数评分为 20 分中的 18 分(范围 11-19)。观察到 18%(11 例中的 2 例)的患者出现轻度炎症后色素沉着过度的唯一不良反应。治疗后,中到重度红斑和水肿通常在 24-48 小时内消退。未观察到其他不良反应。
分馏 CO2 换肤术是治疗色素性皮肤中萎缩性面部利什曼病瘢痕的一种安全、有效且耐受良好的潜在治疗方法。