Karkour Bushra, Abu Ghedda Sedra, Aljundi Rashed, Sheikh Debs Sedra, Farwati Reem, Ishkhanian Silva
Department of Dermatology and Venereology, Aleppo University Hospital, Aleppo, Syria.
Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Skin Health Dis. 2025 Apr 23;5(4):263-272. doi: 10.1093/skinhd/vzaf032. eCollection 2025 Aug.
Atrophic scars, which affect many individuals and arise from various causes, currently lack a standardized treatment protocol. Recent studies suggest that combining microneedling with topical insulin (TI) may offer a promising new approach to improving the appearance of these scars.
To evaluate the efficacy and safety of microneedling combined with TI for treating atrophic scars caused by acne, cutaneous leishmaniasis, striae alba and postoperative wounds. Additionally, we aimed to assess the impact of treatment on improving quality of life.
A total of 158 patients with various types of atrophic scars were divided into two groups: one received microneedling with TI and the other received microneedling with a placebo. Each participant underwent 12 monthly sessions, followed by a 1-year follow-up to assess long-term outcomes. Primary outcomes were measured via the Goodman and Baron qualitative grading system and acne scarring grading system, along with patient satisfaction and Dermatology Life Quality Index scores.
A statistically significant improvement was observed in the TI group, as reported by patients and clinicians, especially regarding postacne and postleishmaniasis scars ( = 0.001). The improvement in quality of life was most pronounced in the postacne group ( = 0.002).
This study suggests that microneedling, when combined with TI, is a safe and effective standalone treatment for atrophic scars resulting from various causes. Additionally, this approach may enhance the quality of life for patients with this condition. However, further research with larger sample sizes is needed to validate these findings.
萎缩性瘢痕影响着许多人，其成因多样，目前缺乏标准化的治疗方案。近期研究表明，微针疗法联合外用胰岛素（TI）可能为改善此类瘢痕外观提供一种有前景的新方法。
评估微针疗法联合TI治疗痤疮、皮肤利什曼病、白色萎缩纹和术后伤口所致萎缩性瘢痕的疗效和安全性。此外，我们旨在评估治疗对改善生活质量的影响。
总共158例患有不同类型萎缩性瘢痕的患者被分为两组：一组接受微针疗法联合TI治疗，另一组接受微针疗法联合安慰剂治疗。每位参与者每月接受12次治疗，随后进行1年的随访以评估长期疗效。主要疗效指标通过古德曼和巴伦定性分级系统、痤疮瘢痕分级系统进行测量，同时评估患者满意度和皮肤病生活质量指数得分。
患者和临床医生报告称，TI组有统计学意义的显著改善，尤其是痤疮后和利什曼病后瘢痕（P = 0.001）。生活质量改善在痤疮后组最为明显（P = 0.002）。
本研究表明，微针疗法联合TI是一种安全有效的、可独立治疗多种原因所致萎缩性瘢痕的方法。此外，这种方法可能会提高患有此类疾病患者的生活质量。然而，需要更大样本量的进一步研究来验证这些发现。
