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协同双靶点水凝胶在体外和体内均提高了紫杉醇的靶向性和抗癌效果。

Synergistic dual-targeting hydrogel improves targeting and anticancer effect of Taxol in vitro and in vivo.

作者信息

Shu Chang, Li Ruixin, Yin Yajun, Yin Deyan, Gu Yueqing, Ding Li, Zhong Wenying

机构信息

Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 211198, P. R. China.

出版信息

Chem Commun (Camb). 2014 Dec 18;50(97):15423-6. doi: 10.1039/c4cc05614k. Epub 2014 Oct 28.

DOI:10.1039/c4cc05614k
PMID:25349928
Abstract

A synergistic dual-targeting molecular self-assembly hydrogel was designed with estrone (Et) and Arg-Gly-Asp (RGD) peptide. Confocal imaging in vitro and real-time visualization in vivo researches were carried out to evidence enhanced targeted delivery and anticancer effect of Taxol.

摘要

设计了一种由雌酮（Et）和精氨酸-甘氨酸-天冬氨酸（RGD）肽组成的协同双靶向分子自组装水凝胶。进行了体外共聚焦成像和体内实时可视化研究，以证明紫杉醇增强的靶向递送和抗癌效果。

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