TargetCompare：一个用于比较同时期miRNA靶标的网络界面。
TargetCompare: A web interface to compare simultaneous miRNAs targets.
作者信息
Moreira Fabiano Cordeiro, Dustan Bruno, Hamoy Igor G, Ribeiro-Dos-Santos André M, Dos Santos Andrea Ribeiro
机构信息
Laboratorio de Genética Humana e Medica, Instituto de Ciências Biológicas, Universidade Federal do Para, Belem, PA, Brasil ; Centro Universitário do Pará - Área de Ciências Exatas e Tecnologia, , Belém, PA, Brasil.
Laboratorio de Genética Humana e Medica, Instituto de Ciências Biológicas, Universidade Federal do Para, Belem, PA, Brasil ; Universidade Federal Rural da Amazônia, Campus de Capanema, PA, Brasil.
出版信息
Bioinformation. 2014 Sep 30;10(9):602-5. doi: 10.6026/97320630010602. eCollection 2014.
UNLABELLED
MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using Java programming language and MySQL database server) to analyse multiple targets of pre-selected miRNAs. We cross validated the tool in eight most highly expressed miRNAs in the antrum region of stomach. This helped to identify 43 potential genes that are target of at least six of the referred miRNAs. The developed tool aims to reduce the randomness and increase the chance of selecting strong candidate target genes and miRNAs responsible for playing important roles in the studied tissue.
AVAILABILITY
未标注
微小RNA（miRNA）是长度在17至25个核苷酸之间的小型非编码核苷酸序列，其主要功能是调控基因表达。由于一个miRNA在复杂的调控细胞信号网络中有数千个预测靶点。因此，同时研究多个靶基因很有意义。因此，我们描述了一个网络工具（使用Java编程语言和MySQL数据库服务器开发）来分析预先选择的miRNA的多个靶点。我们在胃窦区域八个表达最高的miRNA中对该工具进行了交叉验证。这有助于识别43个潜在基因，这些基因是至少六个上述miRNA的靶点。开发的工具旨在减少随机性，增加选择在研究组织中起重要作用的强候选靶基因和miRNA的机会。
可用性
Zotero 插件