Mazor M, Lespessailles E, Coursier R, Daniellou R, Best T M, Toumi H
IPROS, CHRO, EA4708 Orleans University, Orleans, France.
J Cell Mol Med. 2014 Dec;18(12):2340-50. doi: 10.1111/jcmm.12378. Epub 2014 Oct 29.
Articular cartilage damage and subsequent degeneration are a frequent occurrence in synovial joints. Treatment of these lesions is a challenge because this tissue is incapable of quality repair and/or regeneration to its native state. Non-operative treatments endeavour to control symptoms and include anti-inflammatory medications, viscosupplementation, bracing, orthotics and activity modification. Classical surgical techniques for articular cartilage lesions are frequently insufficient in restoring normal anatomy and function and in many cases, it has not been possible to achieve the desired results. Consequently, researchers and clinicians are focusing on alternative methods for cartilage preservation and repair. Recently, cell-based therapy has become a key focus of tissue engineering research to achieve functional replacement of articular cartilage. The present manuscript is a brief review of stem cells and their potential in the treatment of early OA (i.e. articular cartilage pathology) and recent progress in the field.
关节软骨损伤及随后的退变在滑膜关节中很常见。这些损伤的治疗具有挑战性，因为这种组织无法完全修复和/或再生至其原始状态。非手术治疗旨在控制症状，包括使用抗炎药物、关节腔注射透明质酸钠、支具、矫形器以及改变活动方式。用于关节软骨损伤的传统手术技术常常不足以恢复正常的解剖结构和功能，在许多情况下，也无法取得理想的效果。因此，研究人员和临床医生正专注于软骨保存和修复的替代方法。近来，基于细胞的疗法已成为组织工程研究的重点，以实现关节软骨的功能性替代。本手稿简要综述了干细胞及其在早期骨关节炎（即关节软骨病变）治疗中的潜力以及该领域的最新进展。
