Reed S M, Wise M G, Timmerman I
Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284-7792.
J Neuropsychiatry Clin Neurosci. 1989 Winter;1(1):57-60. doi: 10.1176/jnp.1.1.57.
Two patients who developed choreoathetosis in the course of lithium treatment are described, and other cases of choreoathetosis in lithium-treated patients are reviewed. Choreoathetosis is suggested to be a sign of lithium toxicity, almost always accompanied by other signs of neurotoxicity, such as delirium and cerebellar dysfunction. Of the reported cases, 44% developed permanent movement disorders, and 63% of the patients with permanent deficits were taking both lithium and neuroleptic. When choreoathetosis was not permanent, the average duration was seven days after discontinuation of lithium (range, 1 to 90 days).
本文描述了两名在锂治疗过程中出现舞蹈手足徐动症的患者，并回顾了锂治疗患者中其他舞蹈手足徐动症的病例。舞蹈手足徐动症被认为是锂中毒的一个迹象，几乎总是伴有其他神经毒性迹象，如谵妄和小脑功能障碍。在报告的病例中，44%出现了永久性运动障碍，63%有永久性缺陷的患者同时服用锂和抗精神病药物。当舞蹈手足徐动症不是永久性的时候，平均持续时间为停用锂后7天（范围为1至90天）。
