Laboratory of Neural Systems (SisNE), Department of Psychology, Faculdade de Filosofia Ciencias e Letras de Ribeirão Preto, Universidade de São Paulo Ribeirão Preto, Brazil ; Center for Mathematics, Computation and Cognition, Federal University of ABC São Bernardo do Campo, Brazil.
Laboratory of Neural Systems (SisNE), Department of Psychology, Faculdade de Filosofia Ciencias e Letras de Ribeirão Preto, Universidade de São Paulo Ribeirão Preto, Brazil.
Front Comput Neurosci. 2014 Oct 13;8:128. doi: 10.3389/fncom.2014.00128. eCollection 2014.
This work consists of a computational study of the electrical responses of three classes of granule cells of the olfactory bulb to synaptic activation in different dendritic locations. The constructed models were based on morphologically detailed compartmental reconstructions of three granule cell classes of the olfactory bulb with active dendrites described by Bhalla and Bower (1993, pp. 1948-1965) and dendritic spine distributions described by Woolf et al. (1991, pp. 1837-1854). The computational studies with the model neurons showed that different quantities of spines have to be activated in each dendritic region to induce an action potential, which always was originated in the active terminal dendrites, independently of the location of the stimuli, and the morphology of the dendritic tree. These model predictions might have important computational implications in the context of olfactory bulb circuits.
这项工作包括对嗅球三种颗粒细胞在不同树突位置的突触激活的电反应进行计算研究。所构建的模型基于 Bhalla 和 Bower（1993 年，第 1948-1965 页）描述的具有活性树突的嗅球三种颗粒细胞类别的形态详细的分室重建，以及 Woolf 等人描述的树突棘分布（1991 年，第 1837-1854 页）。对模型神经元的计算研究表明，为了在每个树突区域引发动作电位，必须激活不同数量的树突棘，而动作电位总是起源于活性末端树突，而与刺激的位置和树突的形态无关。这些模型预测在嗅球电路的背景下可能具有重要的计算意义。
