Yoo Min, Sharma Neena, Pasnoor Mamatha, Kluding Patricia M
Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, USA.
Department of Neurology, University of Kansas Medical Center, USA.
J Diabetes Metab. 2013 Jun 30;Suppl 10. doi: 10.4172/2155-6156.S10-005.
Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes and a major cause of morbidity and increased mortality. It is typically characterized by significant deficits in tactile sensitivity, vibration sense, lower-limb proprioception, and kinesthesia. Painful diabetic neuropathy (P-DPN) is a common phenotype of DPN that affects up to one-third of the general diabetic population. P-DPN has been shown to be associated with significant reductions in overall quality of life, increased levels of anxiety and depression, sleep impairment, and greater gait variability. The purpose of this review is to examine proposed mechanisms of P-DPN, summarize current treatment regimen, and assess exercise as a potential therapy for P-PDN. Although exercise has been shown to be an effective therapeutic modality for diabetes, its specific effects on DPN and especially the painful phenotype have not been sufficiently investigated in current literature. Several rodent models and clinical trials have presented promising results in this area, and warrant further investigations examining the effect of exercise on P-DPN.
糖尿病周围神经病变（DPN）是糖尿病常见的并发症，也是发病和死亡率增加的主要原因。其典型特征是触觉敏感性、振动觉、下肢本体感觉和运动觉显著减退。痛性糖尿病神经病变（P-DPN）是DPN的常见表型，影响多达三分之一的糖尿病患者。研究表明，P-DPN与总体生活质量显著下降、焦虑和抑郁水平升高、睡眠障碍以及更大的步态变异性有关。本综述的目的是研究P-DPN的潜在机制，总结当前的治疗方案，并评估运动作为P-DPN潜在治疗方法的效果。尽管运动已被证明是治疗糖尿病的有效方式，但目前文献中对其对DPN尤其是痛性表型的具体影响尚未进行充分研究。一些啮齿动物模型和临床试验在这一领域取得了有前景的结果，有必要进一步研究运动对P-DPN的影响。
