Kayode Gbenga A, Amoakoh-Coleman Mary, Agyepong Irene Akua, Ansah Evelyn, Grobbee Diederick E, Klipstein-Grobusch Kerstin
Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands; Ghana Health Service, Greater Accra Region, Accra, Ghana.
PLoS One. 2014 Oct 31;9(10):e109333. doi: 10.1371/journal.pone.0109333. eCollection 2014.
Low birth weight (LBW) remains to be a leading cause of neonatal death and a major contributor to infant and under-five mortality. Its prevalence has not declined in the last decade in sub-Saharan Africa (SSA) and Asia. Some individual level factors have been identified as risk factors for LBW but knowledge is limited on contextual risk factors for LBW especially in SSA.
Contextual risk factors for LBW in Ghana were identified by performing multivariable multilevel logistic regression analysis of 6,900 mothers dwelling in 412 communities that participated in the 2003 and 2008 Demographic and Health Surveys in Ghana.
Contextual-level factors were significantly associated with LBW: Being a rural dweller increased the likelihood of having a LBW infant by 43% (OR 1.43; 95% CI 1.01-2.01; P-value <0.05) while living in poverty-concentrated communities increased the risk of having a LBW infant twofold (OR 2.16; 95% CI 1.29-3.61; P-value <0.01). In neighbourhoods with a high coverage of safe water supply the odds of having a LBW infant reduced by 28% (OR 0.74; 95% CI 0.57-0.96; P-value <0.05).
This study showed contextual risk factors to have independent effects on the prevalence of LBW infants. Being a rural dweller, living in a community with a high concentration of poverty and a low coverage of safe water supply were found to increase the prevalence of LBW infants. Implementing appropriate community-based intervention programmes will likely reduce the occurrence of LBW infants.
低出生体重仍是新生儿死亡的主要原因,也是婴儿及五岁以下儿童死亡的主要因素。在过去十年中,撒哈拉以南非洲(SSA)和亚洲的低出生体重患病率并未下降。一些个体层面的因素已被确定为低出生体重的风险因素,但对于低出生体重的背景风险因素,尤其是在SSA地区,了解仍然有限。
通过对参与2003年和2008年加纳人口与健康调查的412个社区的6900名母亲进行多变量多层次逻辑回归分析,确定加纳低出生体重的背景风险因素。
背景层面的因素与低出生体重显著相关:农村居民生育低出生体重婴儿的可能性增加43%(比值比1.43;95%置信区间1.01 - 2.01;P值<0.05),而生活在贫困集中社区生育低出生体重婴儿的风险增加一倍(比值比2.16;95%置信区间1.29 - 3.61;P值<0.01)。在安全供水覆盖率高的社区,生育低出生体重婴儿的几率降低28%(比值比0.74;95%置信区间0.57 - 0.96;P值<0.05)。
本研究表明背景风险因素对低出生体重婴儿的患病率有独立影响。农村居民、生活在贫困高度集中且安全供水覆盖率低的社区会增加低出生体重婴儿的患病率。实施适当的社区干预计划可能会减少低出生体重婴儿的出现。