Herrington C S, Coates P J, Duprex W P
Medical Research Institute, University of Dundee Medical School, Ninewells Hospital, Dundee, UK.
J Pathol. 2015 Jan;235(2):149-52. doi: 10.1002/path.4476.
Viruses cause a wide range of human diseases, ranging from acute self-resolving conditions to acute fatal diseases. Effects that arise long after the primary infection can also increase the propensity for chronic conditions or lead to the development of cancer. Recent advances in the fields of virology and pathology have been fundamental in improving our understanding of viral pathogenesis, in providing improved vaccination strategies and in developing newer, more effective treatments for patients worldwide. The reviews assembled here focus on the interface between virology and pathology and encompass aspects of both the clinical pathology of viral disease and the underlying disease mechanisms. Articles on emerging diseases caused by Ebola virus, Marburg virus, coronaviruses such as SARS and MERS, Nipah virus and noroviruses are followed by reviews of enteroviruses, HIV infection, measles, mumps, human respiratory syncytial virus (RSV), influenza, cytomegalovirus (CMV) and varicella zoster virus (VZV). The issue concludes with a series of articles reviewing the relationship between viruses and cancer, including the role played by Epstein-Barr virus (EBV) in the pathogenesis of lymphoma and carcinoma; how human papillomaviruses (HPVs) are involved in the development of skin cancer; the involvement of hepatitis B virus infection in hepatocellular carcinoma; and the mechanisms by which Kaposi's sarcoma-associated herpesvirus (KSHV) leads to Kaposi's sarcoma. We hope that this collection of articles will be of interest to a wide range of scientists and clinicians at a time when there is a renaissance in the appreciation of the power of pathology as virologists dissect the processes of disease.
病毒可引发多种人类疾病，范围从急性自限性病症到急性致命疾病。初次感染后很长时间才出现的影响也会增加患慢性病的倾向或导致癌症的发生。病毒学和病理学领域的最新进展对于增进我们对病毒发病机制的理解、提供改进的疫苗接种策略以及为全球患者开发更新、更有效的治疗方法至关重要。这里汇集的综述聚焦于病毒学与病理学的交叉领域，涵盖了病毒性疾病的临床病理学及潜在疾病机制等方面。关于由埃博拉病毒、马尔堡病毒、诸如非典和中东呼吸综合征等冠状病毒、尼帕病毒和诺如病毒引起的新兴疾病的文章之后，是对肠道病毒、艾滋病毒感染、麻疹、腮腺炎、人呼吸道合胞病毒（RSV）、流感、巨细胞病毒（CMV）和水痘带状疱疹病毒（VZV）的综述。该期以一系列综述病毒与癌症关系的文章作为结尾，包括爱泼斯坦 - 巴尔病毒（EBV）在淋巴瘤和癌发病机制中所起的作用；人乳头瘤病毒（HPV）如何参与皮肤癌的发生；乙型肝炎病毒感染与肝细胞癌的关联；以及卡波西肉瘤相关疱疹病毒（KSHV）导致卡波西肉瘤的机制。在病毒学家剖析疾病过程、病理学力量再度受到重视之际，我们希望这组文章能引起广大科学家和临床医生的兴趣。
