Altered induction of the adaptive response to alkylation damage in Escherichia coli recF mutants.
作者信息
Volkert M R
机构信息
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655.
出版信息
J Bacteriol. 1989 Jan;171(1):99-103. doi: 10.1128/jb.171.1.99-103.1989.
Abstract
Escherichia coli recF mutants are hypermutable when treated with methyl methanesulfonate (G. C. Walker, Mol. Gen. Genet. 152:93-103, 1977). In this study, methylation hypermutability of recF mutant strains was examined, and it was found that recF+ is required for normal induction of the adaptive response to alkylation damage. Although this regulatory effect of recF mutations results in reduced levels of enzymes that specifically repair methyl lesions in DNA, it only partially explains the hypermutability. Further examination showed that methylation hypermutability of recF mutant strains required a functional umuDC operon, a component of the SOS response. These results lead to the hypothesis that methylation hypermutability results from the effects of recF mutations on the induction of both the SOS response and the adaptive response.
摘要
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本文引用的文献
1
Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
J Biol Chem. 1956 Jan;218(1):97-106.
2
The SOS regulatory system of Escherichia coli.大肠杆菌的SOS调控系统。
Cell. 1982 May;29(1):11-22. doi: 10.1016/0092-8674(82)90085-x.
3
Control of recA gene RNA in E. coli: regulatory and signal genes.大肠杆菌中recA基因RNA的调控：调控基因和信号基因。
Cell. 1980 Jul;20(3):731-7. doi: 10.1016/0092-8674(80)90319-0.
4
The role of umuC gene product in mutagenesis by simple alkylating agents.umuC基因产物在简单烷基化剂诱变中的作用。
Mol Gen Genet. 1980;177(4):661-5. doi: 10.1007/BF00272677.
5
Genetic recombination of bacterial plasmid DNA. Analysis of the effect of recombination-deficient mutations on plasmid recombination.细菌质粒DNA的基因重组。重组缺陷突变对质粒重组影响的分析。
J Mol Biol. 1982 Sep 25;160(3):411-30. doi: 10.1016/0022-2836(82)90305-9.
6
Effect of the adaptive response on the induction of the SOS pathway in E. coli K-12.适应性反应对大肠杆菌K-12中SOS途径诱导的影响。
Mol Gen Genet. 1980;177(4):653-9. doi: 10.1007/BF00272676.
7
Molecular analysis of the recF gene of Escherichia coli.大肠杆菌recF基因的分子分析
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4622-6. doi: 10.1073/pnas.81.15.4622.
8
Suppression of Escherichia coli recF mutations by recA-linked srfA mutations.recA连锁的srfA突变对大肠杆菌recF突变的抑制作用。
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9
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J Bacteriol. 1983 Dec;156(3):1093-8. doi: 10.1128/jb.156.3.1093-1098.1983.
10
Plasmidic recombination in Escherichia coli K-12: the role of recF gene function.大肠杆菌K-12中的质粒重组：recF基因功能的作用
Mol Gen Genet. 1983;189(3):471-4. doi: 10.1007/BF00325911.
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