Defais M, Jeggo P, Samson L, Schendel P F
Mol Gen Genet. 1980;177(4):653-9. doi: 10.1007/BF00272676.
The adaptive-response is an inducible repair system of E. coli which reduces the mutagenic and cytotoxic effects of alkylation damage (Samson and Cairns, 1977). In adapted cells (cells exposed to sublethal doses of alkylating agents) the induction of W-reactivation and W-mutagenesis by alkylating agents is almost totally blocked. Despite the fact that adaptation has no detectable effect on UV mutagenesis in E. coli K-12, it does inhibit to some extent the UV and tif-1 mediated induction of SOS functions such as W-reactivation and lambda prophage induction. Furthermore, the kinetics of induction of W-mutagenesis following UV treatment are altered by adaptation. In this case the adaptive-response seems to specifically block the induction of an error-producing W-reactivating capacity which normally would increase soon after UV treatment, while affecting error-free W-reactivating systems to a lesser extent.
适应性反应是大肠杆菌的一种诱导性修复系统，可降低烷基化损伤的诱变和细胞毒性作用（Samson和Cairns，1977年）。在适应性细胞（暴露于亚致死剂量烷基化剂的细胞）中，烷基化剂诱导的W-复活和W-诱变几乎完全被阻断。尽管适应性对大肠杆菌K-12中的紫外线诱变没有可检测到的影响，但它确实在一定程度上抑制了紫外线和tif-1介导的SOS功能的诱导，如W-复活和λ原噬菌体诱导。此外，适应性改变了紫外线处理后W-诱变诱导的动力学。在这种情况下，适应性反应似乎特异性地阻断了通常在紫外线处理后不久会增加的产生错误的W-复活能力的诱导，而对无错的W-复活系统的影响较小。
