Shin Jung U, Gantsetseg Dorjsuren, Jung Jin Young, Jung Inhee, Shin Sungsik, Lee Ju Hee
Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
Lasers Surg Med. 2014 Dec;46(10):741-9. doi: 10.1002/lsm.22297. Epub 2014 Nov 3.
Postoperative scarring after thyroidectomy is a problem for both patients and clinicians. Recently, both non-ablative and ablative fractional laser (NFL and AFL) systems have attracted attention as potential therapies for the revision of thyroidectomy scars. The present split-scar study was designed to directly compare the efficacy of these two methods for the treatment of post-thyroidectomy scars.
STUDY DESIGN/MATERIALS AND METHODS: Twenty females (mean age 42.1 years, range 22-55) with scarring 2-3 months post-thyroidectomy were enrolled in the study. One half of the scar (chosen at random) was treated with NFL and the other half was treated with AFL. In each case, two treatments were given at 2-month intervals. Clinical photographs were taken at baseline, before each treatment, and at the final 3-month evaluation. Independent clinician grading of improvement and patient satisfaction were measured on a quartile scale. Color (erythema and melanin indices) and scar hardness were measured at baseline and at three months post-treatment with a dermaspectrometer and durometer, respectively.
The mean clinical improvement grades for AFL and NFL were highly similar, 2.45 ± 0.99 and 2.35 ± 0.85, respectively, without statistical significance (P = 0.752). However, NFL treatment resulted in statistically significant changes in erythema and pigmentation (P = 0.035 and P = 0.003, respectively), and skin hardness was significantly reduced after AFL treatment (P = 0.026).
Clinical improvement was not significantly different between the two systems; however, AFL was better at reducing scar hardness whereas NFL was superior for lightening color. These data suggest that a study assessing the feasibility of a combined approach for the revision of post-thyroidectomy scarring might be warranted.
甲状腺切除术后的瘢痕形成对患者和临床医生来说都是一个问题。近来,非剥脱性和剥脱性点阵激光(NFL和AFL)系统作为甲状腺切除术后瘢痕修复的潜在治疗方法受到关注。本瘢痕分割研究旨在直接比较这两种方法治疗甲状腺切除术后瘢痕的疗效。
研究设计/材料与方法:20名甲状腺切除术后2 - 3个月有瘢痕形成的女性(平均年龄42.1岁,范围22 - 55岁)纳入本研究。瘢痕的一半(随机选择)用NFL治疗,另一半用AFL治疗。在每种情况下,每隔2个月进行两次治疗。在基线、每次治疗前以及最后的3个月评估时拍摄临床照片。独立临床医生对改善情况的分级和患者满意度采用四分制量表进行测量。分别在基线和治疗后3个月用皮肤光谱仪和硬度计测量颜色(红斑和黑色素指数)和瘢痕硬度。
AFL和NFL的平均临床改善等级高度相似,分别为2.45±0.99和2.35±0.85,无统计学意义(P = 0.752)。然而,NFL治疗导致红斑和色素沉着有统计学意义的变化(分别为P = 0.035和P = 0.003),AFL治疗后皮肤硬度显著降低(P = 0.026)。
两种系统的临床改善无显著差异;然而,AFL在降低瘢痕硬度方面更好,而NFL在减轻颜色方面更优。这些数据表明,可能有必要进行一项评估联合方法修复甲状腺切除术后瘢痕形成可行性的研究。