肺孢子菌
Pneumocystis.
作者信息
Gigliotti Francis, Limper Andrew H, Wright Terry
机构信息
Department of Pediatrics, University of Rochester Medical School, Rochester, New York 14642.
Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905.
出版信息
Cold Spring Harb Perspect Med. 2014 Nov 3;4(12):a019828. doi: 10.1101/cshperspect.a019828.
Abstract
Since its initial misidentification as a trypanosome some 100 years ago, Pneumocystis has remained recalcitrant to study. Although we have learned much, we still do not have definitive answers to such basic questions as, where is the reservoir of infection, how does Pneumocystis reproduce, what is the mechanism of infection, and are there true species of Pneumocystis? The goal of this review is to provide the reader the most up to date information available about the biology of Pneumocystis and the disease it produces.
摘要
大约100年前，肺孢子菌最初被误鉴定为锥虫，此后一直难以研究。尽管我们已经了解了很多，但对于一些基本问题，如感染源在哪里、肺孢子菌如何繁殖、感染机制是什么以及是否存在真正的肺孢子菌种，我们仍然没有确切的答案。这篇综述的目的是为读者提供有关肺孢子菌生物学及其所致疾病的最新信息。
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The Pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence.肺孢子菌 Ace2 转录因子调节细胞壁重塑基因和机体毒力。
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Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis.对三种肺孢子菌物种的完整线粒体基因组进行测序和特征分析，为人类和啮齿动物肺孢子菌之间的分化提供了新的见解。
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