诱导多能干细胞在皮肤病学中的应用：潜力、进展与局限
Induced pluripotent stem cells in dermatology: potentials, advances, and limitations.
作者信息
Bilousova Ganna, Roop Dennis R
机构信息
Department of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045 Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.
出版信息
Cold Spring Harb Perspect Med. 2014 Nov 3;4(11):a015164. doi: 10.1101/cshperspect.a015164.
Abstract
The discovery of methods for reprogramming adult somatic cells into induced pluripotent stem cells (iPSCs) has raised the possibility of producing truly personalized treatment options for numerous diseases. Similar to embryonic stem cells (ESCs), iPSCs can give rise to any cell type in the body and are amenable to genetic correction by homologous recombination. These ESC properties of iPSCs allow for the development of permanent corrective therapies for many currently incurable disorders, including inherited skin diseases, without using embryonic tissues or oocytes. Here, we review recent progress and limitations of iPSC research with a focus on clinical applications of iPSCs and using iPSCs to model human diseases for drug discovery in the field of dermatology.
摘要
将成人体细胞重编程为诱导多能干细胞（iPSC）的方法的发现，为众多疾病提供真正个性化治疗方案带来了可能性。与胚胎干细胞（ESC）相似，iPSC可以分化为体内任何细胞类型，并且可通过同源重组进行基因校正。iPSC的这些ESC特性使得无需使用胚胎组织或卵母细胞，就能开发针对许多目前无法治愈的疾病（包括遗传性皮肤病）的永久性矫正疗法。在此，我们综述了iPSC研究的最新进展和局限性，重点关注iPSC的临床应用以及利用iPSC建立人类疾病模型用于皮肤病学领域的药物发现。
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本文引用的文献
1
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.小分子化合物诱导的小鼠体细胞多能干细胞。
Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. Epub 2013 Jul 18.
2
TALEN-based gene correction for epidermolysis bullosa.基于 TALEN 的大疱性表皮松解症基因矫正。
Mol Ther. 2013 Jun;21(6):1151-9. doi: 10.1038/mt.2013.56. Epub 2013 Apr 2.
3
Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming.小分子，大作用——化学操纵干细胞命运和体细胞重编程。
J Cell Sci. 2012 Dec 1;125(Pt 23):5609-20. doi: 10.1242/jcs.096032.
4
RNA-programmed genome editing in human cells.人类细胞中的RNA编程基因组编辑。
Elife. 2013 Jan 29;2:e00471. doi: 10.7554/eLife.00471.
5
Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.表皮发育不良相关患者诱导多能干细胞的上皮细胞分化受损可被小分子化合物 APR-246/PRIMA-1MET 挽救。
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2152-6. doi: 10.1073/pnas.1201753109. Epub 2013 Jan 25.
6
Targeting DNA With Fingers and TALENs.利用锌指核酸酶和转录激活因子样效应物核酸酶靶向DNA
Mol Ther Nucleic Acids. 2012 Jan 24;1(1):e3. doi: 10.1038/mtna.2011.5.
7
Generation of functional multipotent keratinocytes from mouse induced pluripotent stem cells.从小鼠诱导多能干细胞生成功能性多能角质形成细胞。
Methods Mol Biol. 2013;961:337-50. doi: 10.1007/978-1-62703-227-8_22.
8
Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells.诱导多能干细胞或胚胎干细胞分化而来的终末细胞的免疫原性可忽略不计。
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9
RNA-guided human genome engineering via Cas9.通过 Cas9 进行 RNA 引导的人类基因组工程。
Science. 2013 Feb 15;339(6121):823-6. doi: 10.1126/science.1232033. Epub 2013 Jan 3.
10
A molecular roadmap of reprogramming somatic cells into iPS cells.重编程体细胞为诱导多能干细胞的分子路线图。
Cell. 2012 Dec 21;151(7):1617-32. doi: 10.1016/j.cell.2012.11.039.
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