Sansac Caroline, Assou Said, Bouckenheimer Julien, Lemaître Jean-Marc, De Vos John
CHU Montpellier, Institut de Recherche de Médecine Régénératrice et de Biothérapies, Hôpital Saint-Éloi, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France - INSERM, U1183, 34000 Montpellier, France - Université de Montpellier, UFR de Pharmacie, 34000 Montpellier, France.
CHU Montpellier, Institut de Recherche de Médecine Régénératrice et de Biothérapies, Hôpital Saint-Éloi, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France - INSERM, U1183, 34000 Montpellier, France - Université de Montpellier, UFR de Médecine, 34000 Montpellier, France.
Biol Aujourdhui. 2016;210(1):1-8. doi: 10.1051/jbio/2016013. Epub 2016 Jun 10.
Induced pluripotent stem cells (iPSCs) are obtained by reprogramming differentiated cells through forced expression of four embryonic transcription factors. The discovery of this technology, able to transform a differentiated cell into a pluripotent cell, has profoundly shifted the paradigm of the concept of cell identity, since it is now possible to obtain in vitro any cell type from an initial sample of skin or blood cells from a healthy volunteer or patient. Applications of iPSCs are exceedingly large, and comprise the in vitro modeling of normal or pathological tissues, including for massive drug screening. They also open new therapeutic avenues in the field of regenerative medicine.
诱导多能干细胞（iPSC）是通过强制表达四种胚胎转录因子对分化细胞进行重编程而获得的。这项能够将分化细胞转化为多能细胞的技术的发现，深刻地改变了细胞身份概念的范式，因为现在可以从健康志愿者或患者的皮肤或血细胞初始样本中在体外获得任何细胞类型。iPSC的应用极为广泛，包括正常或病理组织的体外建模，用于大规模药物筛选。它们还在再生医学领域开辟了新的治疗途径。
