Jung Kyoung In, Jung Younhea, Park Kyoung Tae, Park Chan Kee
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Invest Ophthalmol Vis Sci. 2014 Nov 4;55(12):7709-15. doi: 10.1167/iovs.14-13957.
To investigate factors associated with irreversible components of anterior lamina cribrosa (LC) depth in glaucoma patients.
A total of 141 glaucoma patients and 51 healthy control subjects were enrolled. The optic nerve head (ONH) was imaged using the enhanced depth imaging (EDI) modes of Spectralis optical coherence tomography (OCT). The depth of the LC was measured at the midhorizontal, superior, and inferior midperipheral regions of the ONH of each eye. Analyzed factors associated LC depth included age, axial length, intraocular pressure (IOP), disc size, central corneal thickness, average retinal nerve fiber layer (RNFL) thickness, and mean deviation (MD).
In glaucoma patients, the LC was more deeply located compared with the control group at the midhorizontal and superior and inferior midperipheral B-scans (All P < 0.001). Age, initial IOP, and treated IOP was correlated with mean LC depth (All P < 0.001), and those correlations remained after adjusting for MD and RNFL thickness (All P < 0.001). In multivariate analysis, younger age, high untreated IOP, and thinner RNFL thickness was significantly associated with a deeper LC (P = 0.015, <0.001, and 0.042). There was an interaction between age and MD as predictors for LC depth (P = 0.007).
The anterior LC surface is more deeply located in glaucoma patients compared with healthy controls. In glaucoma patients, age, initial IOP, and RNFL thickness were influential factors related to LC depth. These factors should be considered in clinical application of plastic LC displacement in glaucoma patients.
研究青光眼患者前筛板（LC）深度不可逆成分的相关因素。
共纳入141例青光眼患者和51例健康对照者。使用Spectralis光学相干断层扫描（OCT）的增强深度成像（EDI）模式对视神经乳头（ONH）进行成像。在每只眼睛ONH的水平中部、上方和下方中周区域测量LC的深度。分析的与LC深度相关的因素包括年龄、眼轴长度、眼压（IOP）、视盘大小、中央角膜厚度、平均视网膜神经纤维层（RNFL）厚度和平均偏差（MD）。
在青光眼患者中，与对照组相比，在水平中部以及上方和下方中周B扫描中LC的位置更深（所有P<0.001）。年龄、初始眼压和治疗后眼压与平均LC深度相关（所有P<0.001），在调整MD和RNFL厚度后这些相关性仍然存在（所有P<0.001）。在多变量分析中，年龄较小、未治疗时眼压较高和RNFL厚度较薄与LC较深显著相关（P=0.015、<0.001和0.042）。年龄和MD作为LC深度预测指标之间存在交互作用（P=0.007）。
与健康对照者相比，青光眼患者的前LC表面位置更深。在青光眼患者中，年龄、初始眼压和RNFL厚度是与LC深度相关的影响因素。在青光眼患者进行可塑LC移位的临床应用中应考虑这些因素。
