Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Ophthalmology. 2013 Sep;120(9):1798-803. doi: 10.1016/j.ophtha.2013.02.015. Epub 2013 Apr 25.
To evaluate the features of the lamina cribrosa (LC) in pseudoexfoliation glaucoma (PXG) patients using enhanced depth imaging (EDI) of spectral-domain optical coherence tomography (SD OCT). The results were compared with those of patients with primary open-angle glaucoma (POAG).
Cross-sectional study.
Patients with PXG (n = 21) and POAG (n = 35) matched for age and visual field mean deviation (VF MD).
Participants were imaged using SD OCT. Lamina cribrosa thickness (LT) and anterior lamina cribrosa depth (ALD) were determined at 3 areas (mid superior, center, and mid inferior) by 2 examiners using an EDI mode of the optic nerve head.
The LT and ALD were compared between PXG and POAG eyes.
Mean ± standard deviation baseline untreated intraocular pressure was not significantly different between the 2 groups (PXG, 18.3 ± 8.2 mmHg; POAG, 15.3 ± 3.4 mmHg; P = 0.310). The mean VF MD was -12.7 ± 9.0 dB in the PXG group versus -11.6 ± 9.1 dB in the POAG group (P = 0.643). When compared with the POAG group, the PXG group demonstrated a significantly thinner LT in all 3 areas and a thinner mean LT (133.4 ± 14.5 μm in the POAG group vs. 121.3 ± 13.0 μm in the PXG group; P<0.001). Anterior lamina cribrosa depth did not demonstrate a significant difference in any of the 3 areas between both groups (mean ALD, 324.3 ± 91.9 μm in the POAG group vs. 358.7 ± 142.7 μm in the PXG group; P = 0.470). Of 21 eyes in the PXG group, 9 eyes demonstrated a unilateral clinical presentation. When we compared the PXG eyes and the apparently normal-looking fellow eyes of those 9 eyes, neither the LT nor ALD demonstrated a significant difference (P = 0.223 and P = 0.079, respectively).
Eyes with PXG demonstrate a thinner LC compared with POAG eyes at similar levels of glaucoma severity.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
利用频域光学相干断层扫描（SD-OCT）的增强深度成像（EDI）评估假性剥脱性青光眼（PXG）患者的筛板（LC）特征。将结果与原发性开角型青光眼（POAG）患者进行比较。
横断面研究。
年龄和视野平均偏差（VF MD）匹配的 PXG（n=21）和 POAG（n=35）患者。
使用 SD-OCT 对参与者进行成像。通过两位检查者使用视神经头的 EDI 模式，在 3 个区域（中上、中央和中下）确定筛板厚度（LT）和前筛板深度（ALD）。
比较 PXG 和 POAG 眼的 LT 和 ALD。
两组间未治疗的基础眼压的平均值±标准差无显著差异（PXG 组，18.3±8.2mmHg；POAG 组，15.3±3.4mmHg；P=0.310）。PXG 组的平均 VF MD 为-12.7±9.0dB，POAG 组为-11.6±9.1dB（P=0.643）。与 POAG 组相比，PXG 组在所有 3 个区域的 LT 均明显变薄，平均 LT 也更薄（POAG 组为 133.4±14.5μm，PXG 组为 121.3±13.0μm；P<0.001）。两组间 3 个区域的前筛板深度均无显著差异（POAG 组平均 ALD 为 324.3±91.9μm，PXG 组为 358.7±142.7μm；P=0.470）。在 PXG 组的 21 只眼中，9 只眼表现为单侧临床表现。当我们比较 PXG 眼和这 9 只眼的正常外观对侧眼时，LT 和 ALD 均无显著差异（P=0.223 和 P=0.079）。
在相似严重程度的青光眼水平下，PXG 眼的 LC 比 POAG 眼更薄。
作者没有与本文讨论的任何材料有关的专有或商业利益。
