Comucci Eleonora Beltrame, Vasques Ana Carolina Junqueira, Geloneze Bruno, Calixto Antonio Ramos, Pareja José Carlos, Tambascia Marcos Antonio
Laboratory of Investigation on Metabolism and Diabetes, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
Arq Bras Endocrinol Metabol. 2014 Oct;58(7):709-14. doi: 10.1590/0004-2730000002431.
Retinol-binding protein 4 (RBP4) is an adipokine responsible for vitamin A (retinol) transportation. Studies associated RBP4 increased levels with severity of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). The study aimed to quantify RBP4 serum standards in women with a wide range of body mass index (BMI) and glucose tolerance level.
Cross-sectional study was performed with 139 women divided into three groups: Group 1 (lean-control, n = 45) and Group 2 (obese, n = 53) with normal glucose tolerance and group 3 (obese with T2DM, n = 41), called G1, G2 and G3. Were assessed clinical, biochemical, anthropometric and body composition parameters.
According to data analysis, we obtained in G1 higher RBP4 levels (104.8 ± 76.8 ng/mL) when compared to G2 (87.9 ± 38 ng/mL) and G3 (72.2 ± 15.6 ng/mL) levels. Also, were found: in G1 positive correlations of RBP4 with BMI (r = 0.253), glycated hemoglobin (r = 0.378) and fasting insulin (r = 0.336); in G2 with glycated hemoglobin (r = 0.489); in G3 with glycated hemoglobin (r = 0.330), fasting glucose (r = 0.463), HOMA-IR (r = 0.481).
Although RBP4 have shown lower levels in diabetic and obese, a strong correlation with HOMA-IR index highlights that, in our study, there is growing IR when there is an increasing in RBP4 levels.
视黄醇结合蛋白4（RBP4）是一种负责维生素A（视黄醇）运输的脂肪因子。研究表明，RBP4水平升高与2型糖尿病（T2DM）的严重程度和胰岛素抵抗（IR）相关。本研究旨在量化不同体重指数（BMI）和糖耐量水平女性的血清RBP4标准。
对139名女性进行横断面研究，分为三组：糖耐量正常的第1组（瘦对照组，n = 45）和第2组（肥胖组，n = 53），以及第3组（肥胖合并T2DM组，n = 41），分别称为G1、G2和G3。评估临床、生化、人体测量和身体成分参数。
数据分析显示，与G2组（87.9±38 ng/mL）和G3组（72.2±15.6 ng/mL）相比，G1组的RBP4水平更高（104.8±76.8 ng/mL）。此外，还发现：在G1组中，RBP4与BMI（r = 0.253）、糖化血红蛋白（r = 0.378）和空腹胰岛素（r = 0.336）呈正相关；在G2组中，RBP4与糖化血红蛋白（r = 0.489）呈正相关；在G3组中，RBP4与糖化血红蛋白（r = 0.330）、空腹血糖（r = 0.463）、HOMA-IR（r = 0.481）呈正相关。
尽管糖尿病和肥胖患者的RBP4水平较低，但与HOMA-IR指数的强相关性表明，在我们的研究中，随着RBP4水平的升高，胰岛素抵抗也在增加。
