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异丙肾上腺素和二丁酰腺苷环3',5'-单磷酸对正常甲状腺和甲状腺功能减退大鼠培养松果体中甲状腺素5'-脱碘酶活性刺激作用的比较。

Comparison of isoproterenol and dibutyryl adenosine cyclic 3',5'-monophosphate stimulation of thyroxine 5'-deiodinase activity in cultured pineal glands from euthyroid and hypothyroid rats.

作者信息

Murakami M, Greer S E, McAdams S, Greer M A

机构信息

Department of Medicine, Oregon Health Sciences University, Portland 97201.

出版信息

Life Sci. 1989;44(6):425-9. doi: 10.1016/0024-3205(89)90267-1.

DOI:10.1016/0024-3205(89)90267-1
PMID:2537451
Abstract

Thyroxine 5'-deiodinase was increased by isoproterenol and dibutyryl adenosine cyclic 3',5'-monophosphate in a dose- and time-related manner in cultured rat pineal gland. Basal and stimulated activity was higher in glands from hypothyroid than from euthyroid animals. Our data suggest direct beta-adrenergic stimulation of intracellular cyclic AMP may be involved in the regulation of pineal thyroxine 5'-deiodinase activity.

摘要

在培养的大鼠松果体中，异丙肾上腺素和二丁酰腺苷环化3',5'-单磷酸以剂量和时间相关的方式增加了甲状腺素5'-脱碘酶的活性。甲状腺功能减退动物的松果体中，基础活性和刺激活性均高于甲状腺功能正常的动物。我们的数据表明，细胞内环磷酸腺苷的直接β-肾上腺素能刺激可能参与松果体甲状腺素5'-脱碘酶活性的调节。

相似文献

1
Comparison of isoproterenol and dibutyryl adenosine cyclic 3',5'-monophosphate stimulation of thyroxine 5'-deiodinase activity in cultured pineal glands from euthyroid and hypothyroid rats.异丙肾上腺素和二丁酰腺苷环3',5'-单磷酸对正常甲状腺和甲状腺功能减退大鼠培养松果体中甲状腺素5'-脱碘酶活性刺激作用的比较。
Life Sci. 1989;44(6):425-9. doi: 10.1016/0024-3205(89)90267-1.
2
Effect of isoproterenol and dibutyryl cyclic AMP on thyroxine type-II 5'-deiodinase and N-acetyltransferase activities in rat pineal organ cultures.异丙肾上腺素和二丁酰环磷腺苷对大鼠松果体器官培养物中甲状腺素II型5'-脱碘酶和N-乙酰转移酶活性的影响。
Neurosci Lett. 1988 Jun 29;89(2):229-33. doi: 10.1016/0304-3940(88)90386-2.
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Vasoactive intestinal peptide stimulates type II thyroxine 5'-deiodinase and N-acetyltransferase activities in dispersed pineal cells of euthyroid and hypothyroid rats.血管活性肠肽刺激正常甲状腺和甲状腺功能减退大鼠的松果体分散细胞中的II型甲状腺素5'-脱碘酶和N-乙酰转移酶活性。
Neurosci Lett. 1993 Mar 19;151(2):130-3. doi: 10.1016/0304-3940(93)90003-4.
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The role of the superior cervical ganglia in the nocturnal rise of pineal type-II thyroxine 5'-deiodinase activity.颈上神经节在松果体II型甲状腺素5'-脱碘酶活性夜间升高过程中的作用。
Brain Res. 1988 Jan 12;438(1-2):366-8. doi: 10.1016/0006-8993(88)91365-0.
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Adenosine effects on the rat pineal gland in vitro: cyclic adenosine monophosphate levels, N-acetyltransferase, and thyroxine type II 5'-deiodinase activities and melatonin production.腺苷对体外培养的大鼠松果体的影响：环磷酸腺苷水平、N-乙酰转移酶、Ⅱ型甲状腺素5'-脱碘酶活性及褪黑素生成
J Pineal Res. 1991 Aug;11(1):1-6. doi: 10.1111/j.1600-079x.1991.tb00819.x.
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Effect of thyroid status on catecholamine stimulation of thyroxine 5'-deiodinase in brown adipocytes.
Am J Physiol. 1989 Jan;256(1 Pt 1):E74-9. doi: 10.1152/ajpendo.1989.256.1.E74.
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In vivo stimulation of rat pineal type II thyroxine 5'-deiodinase activity by either norepinephrine or isoproterenol.去甲肾上腺素或异丙肾上腺素对大鼠松果体II型甲状腺素5'-脱碘酶活性的体内刺激作用。
Proc Soc Exp Biol Med. 1990 Sep;194(4):327-31. doi: 10.3181/00379727-194-43099.
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Type-II thyroxine 5'-deiodinase is present in the rat pineal gland.II型甲状腺素5'-脱碘酶存在于大鼠松果体中。
Biochem Biophys Res Commun. 1986 Jun 13;137(2):863-8. doi: 10.1016/0006-291x(86)91159-9.
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Evidence that rat pineal thyroxine 5'-deiodinase is primarily stimulated by beta- and not alpha-adrenergic agonists and that its adrenergic-stimulated and spontaneous rhythmic nocturnal rise require RNA and protein synthesis.有证据表明，大鼠松果体甲状腺素5'-脱碘酶主要受β-而非α-肾上腺素能激动剂刺激，且其受肾上腺素能刺激的夜间节律性自发升高需要RNA和蛋白质合成。
Proc Soc Exp Biol Med. 1989 Feb;190(2):190-4. doi: 10.3181/00379727-190-42849.
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Stimulatory effect of isoproterenol but not of dibutyryl cyclic AMP on N-acetyltransferase activity and melatonin content of Syrian hamster pineal gland in organ culture.异丙肾上腺素而非二丁酰环磷腺苷对器官培养的叙利亚仓鼠松果体N-乙酰转移酶活性和褪黑素含量的刺激作用。
Neuroendocrinology. 1988 Sep;48(3):229-34. doi: 10.1159/000125016.

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2
Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.600多个基因在松果体中的昼夜表达变化：肾上腺素能/cAMP信号传导的核心作用
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