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II型甲状腺素5'-脱碘酶存在于大鼠松果体中。

Type-II thyroxine 5'-deiodinase is present in the rat pineal gland.

作者信息

Tanaka K, Murakami M, Greer M A

出版信息

Biochem Biophys Res Commun. 1986 Jun 13;137(2):863-8. doi: 10.1016/0006-291x(86)91159-9.

DOI:10.1016/0006-291x(86)91159-9
PMID:3729943
Abstract

Thyroxine-5'-deiodinase has been identified in the rat pineal gland. The characteristics of the enzyme are compatible with a Type-II deiodinase which is tissue-specific and presumably related to generating a local action of thyroid hormone. Our data suggest there may be a previously unrecognized role of thyroid hormone in the regulation of pineal activity.

摘要

甲状腺素5'-脱碘酶已在大鼠松果体中被鉴定出来。该酶的特性与II型脱碘酶相符，后者具有组织特异性，可能与甲状腺激素产生局部作用有关。我们的数据表明，甲状腺激素在松果体活动调节中可能存在以前未被认识到的作用。

相似文献

1
Type-II thyroxine 5'-deiodinase is present in the rat pineal gland.II型甲状腺素5'-脱碘酶存在于大鼠松果体中。
Biochem Biophys Res Commun. 1986 Jun 13;137(2):863-8. doi: 10.1016/0006-291x(86)91159-9.
2
Comparison of isoproterenol and dibutyryl adenosine cyclic 3',5'-monophosphate stimulation of thyroxine 5'-deiodinase activity in cultured pineal glands from euthyroid and hypothyroid rats.异丙肾上腺素和二丁酰腺苷环3',5'-单磷酸对正常甲状腺和甲状腺功能减退大鼠培养松果体中甲状腺素5'-脱碘酶活性刺激作用的比较。
Life Sci. 1989;44(6):425-9. doi: 10.1016/0024-3205(89)90267-1.
3
Rhythmicity of triiodothyronine generation by type II thyroxine 5'-deiodinase in rat pineal is mediated by a beta-adrenergic mechanism.大鼠松果体中II型甲状腺素5'-脱碘酶生成三碘甲状腺原氨酸的节律性由β-肾上腺素能机制介导。
Endocrinology. 1987 Jul;121(1):74-7. doi: 10.1210/endo-121-1-74.
4
Thyroxine type II 5'-deiodinase activity in pineal and Harderian gland is enhanced by hypothyroidism but is independent of serum thyroxine concentrations during hyperthyroidism.甲状腺功能减退可增强松果体和哈德氏腺中Ⅱ型甲状腺素5'-脱碘酶的活性，但在甲状腺功能亢进期间，该酶活性与血清甲状腺素浓度无关。
Int J Biochem. 1993 Jul;25(7):1041-6. doi: 10.1016/0020-711x(93)90119-y.
5
Adrenalectomy or superior cervical ganglionectomy modifies the nocturnal increase in rat pineal type II thyroxine 5'-deiodinase.肾上腺切除术或颈上神经节切除术可改变大鼠松果体II型甲状腺素5'-脱碘酶的夜间增加。
Chronobiol Int. 1993 Apr;10(2):87-93. doi: 10.1080/07420529309059696.
6
The role of the superior cervical ganglia in the nocturnal rise of pineal type-II thyroxine 5'-deiodinase activity.颈上神经节在松果体II型甲状腺素5'-脱碘酶活性夜间升高过程中的作用。
Brain Res. 1988 Jan 12;438(1-2):366-8. doi: 10.1016/0006-8993(88)91365-0.
7
Type II thyroxine 5'-deiodinase activity in the rat brown adipose tissue, pineal gland, Harderian gland, and cerebral cortex: effect of acute cold exposure and lack of relationship to pineal melatonin synthesis.
J Pineal Res. 1990;9(2):159-66. doi: 10.1111/j.1600-079x.1990.tb00704.x.
8
Vasoactive intestinal peptide stimulates type II thyroxine 5'-deiodinase and N-acetyltransferase activities in dispersed pineal cells of euthyroid and hypothyroid rats.血管活性肠肽刺激正常甲状腺和甲状腺功能减退大鼠的松果体分散细胞中的II型甲状腺素5'-脱碘酶和N-乙酰转移酶活性。
Neurosci Lett. 1993 Mar 19;151(2):130-3. doi: 10.1016/0304-3940(93)90003-4.
9
Thyroxine 5'-deiodinase activity in pineal gland and frontal cortex: nighttime increase and the effect of either continuous light exposure or superior cervical ganglionectomy.甲状腺素5'-脱碘酶在松果体和额叶皮质中的活性：夜间升高以及持续光照或颈上神经节切除术的影响。
Endocrinology. 1988 Jan;122(1):236-41. doi: 10.1210/endo-122-1-236.
10
Nocturnal increases in the triiodothyronine/thyroxine ratio in the rat thymus and pineal gland follow increases of type II 5'-deiodinase activity.大鼠胸腺和松果体中三碘甲状腺原氨酸/甲状腺素比值的夜间升高是在II型5'-脱碘酶活性增加之后出现的。
Int J Biochem Cell Biol. 1998 Feb;30(2):235-41. doi: 10.1016/s1357-2725(97)00116-7.

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Endocr Rev. 2008 Dec;29(7):898-938. doi: 10.1210/er.2008-0019. Epub 2008 Sep 24.
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Thyroid hormone deiodinases revisited: insights from lungfish: a review.
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6
Adrenergic control of induction of type II iodothyronine 5'-deiodinase activity in cultured mouse brown adipocytes.培养的小鼠棕色脂肪细胞中Ⅱ型碘甲状腺原氨酸5'-脱碘酶活性诱导的肾上腺素能调控
Biochem J. 1993 May 15;292 ( Pt 1)(Pt 1):303-8. doi: 10.1042/bj2920303.
7
Potentiating effect of phenylephrine on isoproterenol activation of thyroxine type II deiodinase in the pineal gland of adult rats.
Experientia. 1993 Apr 15;49(4):329-31. doi: 10.1007/BF01923413.
8
Differential responses of rat pineal thyroxine type II 5'-deiodinase and N-acetyltransferase activities to either light exposure, isoproterenol, phenylephrine, or propranolol.大鼠松果体II型甲状腺素5'-脱碘酶和N-乙酰转移酶活性对光照、异丙肾上腺素、去氧肾上腺素或普萘洛尔的不同反应。
Cell Mol Neurobiol. 1988 Dec;8(4):447-58. doi: 10.1007/BF00711228.