Watzl Carsten, Urlaub Doris, Fasbender Frank, Claus Maren
IfADo - Leibniz Research Centre for Working Environment and Human Factors Ardeystrasse 67, 44139 Dortmund Germany.
F1000Prime Rep. 2014 Oct 1;6:87. doi: 10.12703/P6-87. eCollection 2014.
Natural killer (NK) cells are lymphocytes that are important for early and effective immune responses against infections and cancer. In the last 40 years, many receptors, their corresponding ligands and signaling pathways that regulate NK cell functions have been identified. However, we now know that additional processes, such as NK cell education, differentiation and also the formation of NK cell memory, have a great impact on the reactivity of these cells. Here, we summarize the current knowledge about these modulatory processes.
自然杀伤（NK）细胞是淋巴细胞，对于针对感染和癌症的早期有效免疫反应至关重要。在过去40年中，已经鉴定出许多调节NK细胞功能的受体、其相应的配体和信号通路。然而，我们现在知道，其他过程，如NK细胞的教育、分化以及NK细胞记忆的形成，对这些细胞的反应性有很大影响。在这里，我们总结了关于这些调节过程的当前知识。
