Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA
Centre d'Immunologie de Marseille-Luminy UM2 Aix-Marseille Université, Marseille, France INSERM U1104, Marseille, France CNRS UMR7280, Marseille, France.
EMBO J. 2014 Jun 17;33(12):1295-303. doi: 10.1002/embj.201387651. Epub 2014 Mar 27.
Immune memory has traditionally been the domain of the adaptive immune system, present only in antigen-specific T and B cells. The purpose of this review is to summarize the evidence for immunological memory in lower organisms (which are not thought to possess adaptive immunity) and within specific cell subsets of the innate immune system. A special focus will be given to recent findings in both mouse and humans for specificity and memory in natural killer (NK) cells, which have resided under the umbrella of innate immunity for decades. The surprising longevity and enhanced responses of previously primed NK cells will be discussed in the context of several immunization settings.
免疫记忆传统上是适应性免疫系统的领域,仅存在于抗原特异性 T 和 B 细胞中。本文的目的是总结低等生物(被认为不具有适应性免疫)和固有免疫系统特定细胞亚群中免疫记忆的证据。特别关注近年来在小鼠和人类中发现的自然杀伤 (NK) 细胞的特异性和记忆,这些细胞在数十年中一直被归类为固有免疫细胞。将讨论先前被激活的 NK 细胞的惊人的长寿和增强的反应,以及它们在几种免疫接种环境中的作用。