Charles Luenda E, Fekedulegn Desta, Landsbergis Paul, Burchfiel Cecil M, Baron Sherry, Kaufman Joel D, Stukovsky Karen Hinckley, Fujishiro Kaori, Foy Capri G, Andrew Michael E, Diez Roux Ana V
From the Biostatistics and Epidemiology Branch (Drs Charles, Fekedulegn, Burchfiel, and Andrew), Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV; Department of Environmental and Occupational Health Sciences (Dr Landsbergis), State University of New York Downstate Medical Center, NY, and State University of New York Downstate School of Public Health, Brooklyn, NY; Division of Surveillance, Hazard Evaluation, and Field Studies (Drs Baron and Fujishiro), National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH; Department of Environmental and Occupational Health Sciences (Dr Kaufman), School of Public Health, University of Washington, Seattle, WA; Department of Biostatistics (Ms Stukovsky), School of Public Health, University of Washington, Seattle, WA; Department of Social Sciences and Health Policy (Dr Foy), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC; and School of Public Health (Dr Diez Roux), Drexel University, Philadelphia, PA. Research was conducted at the Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.
J Occup Environ Med. 2014 Nov;56(11):1153-60. doi: 10.1097/JOM.0000000000000311.
To investigate associations of work hours, job control, job demands, job strain, and occupational category with brachial artery flow-mediated dilation (FMD) in 1499 Multi-Ethnic Study of Atherosclerosis participants.
Flow-mediated dilation was obtained using high-resolution ultrasound. Mean values of FMD were examined across categories of occupation, work hours, and the other exposures using regression analyses.
Occupational category was significantly associated with FMD overall, with blue-collar workers showing the lowest mean values-management/professional = 4.97 ± 0.22%; sales/office = 5.19 ± 0.28%; services = 4.73 ± 0.29%; and blue-collar workers = 4.01 ± 0.26% (adjusted P < 0.001). There was evidence of effect modification by sex (interaction P = 0.031)-significant associations were observed among women (adjusted P = 0.002) and nearly significant results among men (adjusted P = 0.087). Other exposures were not significantly associated with FMD.
Differences in endothelial function may account for some of the variation in cardiovascular disease across occupational groups.
在1499名动脉粥样硬化多民族研究参与者中，调查工作时长、工作控制、工作需求、工作压力和职业类别与肱动脉血流介导的血管舒张（FMD）之间的关联。
使用高分辨率超声获得血流介导的血管舒张数据。通过回归分析，对职业、工作时长及其他暴露因素各分类下的FMD均值进行检验。
总体而言，职业类别与FMD显著相关，蓝领工人的均值最低——管理/专业人员=4.97±0.22%；销售/办公室职员=5.19±0.28%；服务行业人员=4.73±0.29%；蓝领工人=4.01±0.26%（校正P<0.001）。有证据表明存在性别交互作用（交互P=0.031）——在女性中观察到显著关联（校正P=0.002），在男性中结果接近显著（校正P=0.087）。其他暴露因素与FMD无显著关联。
内皮功能差异可能是不同职业群体心血管疾病差异的部分原因。
