Podoshin L, Fradis M, Ben David J
Department of Otolaryngology, Haifa Medical Center (Rothschild), Faculty of Medicine, Israel.
J Laryngol Otol. 1989 Jan;103(1):46-50. doi: 10.1017/s0022215100108011.
The sensorineural hearing loss in 150 patients with chronic otitis media who were treated in the Haifa Medical Center (Rothschild) during a ten year period was studied. There were 124 patients treated with a mixture containing neomycin, polymyxin B and dexamethasone and a control group of 26 patients with dexamethasone only. All patients were followed up for a period of 1-2 years. Patients with hearing loss due to factors such as previous ear surgery, family history, exposure to noise etc., have been excluded. The conclusions reached were that there is a relationship between the period of disease and the sensorineural hearing loss and that the local treatment with a mixture containing neomycin + polymyxin B appears to contribute to the worsening of the sensorineural hearing loss in patients with chronic otitis media. Our numbers are small and further studies must be done, but the fact that currently used ear drops may produce a sensorineural hearing loss should not be ignored.
对在海法医疗中心（罗斯柴尔德）接受治疗的150例慢性中耳炎患者在十年期间出现的感音神经性听力损失进行了研究。其中124例患者接受了含有新霉素、多粘菌素B和地塞米松的混合药物治疗，另有26例患者组成对照组，仅使用地塞米松治疗。所有患者均接受了1至2年的随访。因既往耳部手术、家族史、噪声暴露等因素导致听力损失的患者被排除在外。得出的结论是，病程与感音神经性听力损失之间存在关联，并且使用含有新霉素+多粘菌素B的混合物进行局部治疗似乎会导致慢性中耳炎患者的感音神经性听力损失恶化。我们的样本数量较少，必须开展进一步研究，但目前使用的滴耳液可能会导致感音神经性听力损失这一事实不容忽视。
