Vo Thanh-Sang, Ngo Dai-Hung, Kang Kyong-Hwa, Jung Won-Kyo, Kim Se-Kwon
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea.
Mol Nutr Food Res. 2015 Jan;59(1):129-38. doi: 10.1002/mnfr.201400412. Epub 2014 Dec 5.
Marine polysaccharides have been found as the principle component in cell wall structures of seaweeds or exoskeletons of crustaceans. Due to numerous pharmaceutical properties of marine polysaccharides such as antioxidant, anti-inflammatory, antiallergic, antitumor, antiobesity, antidiabetes, anticoagulant, antiviral, immunomodulatory, cardioprotective, and antihepatopathy activities, they have been applied in many fields of biomaterials, food, cosmetic, and pharmacology. Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been evidenced as downregulators of allergic responses due to enhancement of innate immune system, alteration of Th1/Th2 balance forward to Th1 cells, inhibition of IgE production, and suppression of mast cell degranulation. This contribution, therefore, focuses on antiallergic properties of marine polysaccharides and emphasizes their potential application as bioactive food ingredients as well as nutraceuticals for prevention of allergic disorders.
海洋多糖已被发现是海藻细胞壁结构或甲壳类动物外骨骼的主要成分。由于海洋多糖具有多种药理特性，如抗氧化、抗炎、抗过敏、抗肿瘤、抗肥胖、抗糖尿病、抗凝血、抗病毒、免疫调节、心脏保护和抗肝病活性，它们已被应用于生物材料、食品、化妆品和药理学等许多领域。最近，几种海洋多糖，如藻酸盐、紫菜聚糖、岩藻依聚糖、几丁质及其衍生物，已被证明是过敏反应的下调因子，因为它们能增强先天免疫系统、使Th1/Th2平衡向Th1细胞方向改变、抑制IgE产生并抑制肥大细胞脱颗粒。因此，本文着重介绍海洋多糖的抗过敏特性，并强调它们作为生物活性食品成分以及预防过敏性疾病的营养保健品的潜在应用。
