海藻中海洋多糖的抗病毒活性及作用机制概述

Overview on the antiviral activities and mechanisms of marine polysaccharides from seaweeds.

作者信息

Shi Qimin, Wang Anjian, Lu Zhonghua, Qin Chunjun, Hu Jing, Yin Jian

机构信息

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Lihu Avenue1800, Wuxi 214122, China.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Lihu Avenue1800, Wuxi 214122, China; Wuxi No.5 People's Hospital, Xingyuan Rd. 88, Wuxi 214002, China.

出版信息

Carbohydr Res. 2017 Dec 1;453-454:1-9. doi: 10.1016/j.carres.2017.10.020. Epub 2017 Oct 31.

DOI:10.1016/j.carres.2017.10.020

PMID:29102716

Abstract

Marine polysaccharides are attracting increasing attention in medical and pharmaceutical development because of their important biological properties. The seaweed polysaccharides have now become a rich resource of potential antiviral drugs due to their antiviral activities against various viruses. The structural diversity and complexity of marine polysaccharides and their derivatives contribute to their antiviral activities in different phases of many different viral infection processes. This review mainly introduces the different types of seaweed polysaccharides and their derivatives with potent antiviral activities. Moreover, the antiviral mechanisms and medical applications of certain marine polysaccharides from seaweeds are also demonstrated.

摘要

由于其重要的生物学特性，海洋多糖在医学和药物开发中越来越受到关注。海藻多糖因其对多种病毒的抗病毒活性，现已成为潜在抗病毒药物的丰富来源。海洋多糖及其衍生物的结构多样性和复杂性促成了它们在许多不同病毒感染过程的不同阶段的抗病毒活性。本综述主要介绍了具有强大抗病毒活性的不同类型的海藻多糖及其衍生物。此外，还展示了某些海藻海洋多糖的抗病毒机制和医学应用。