Liang Sudong, Lv Gaofei, Chen Weikai, Jiang Jianxin, Wang Jingqun
Department of Urology, Gaoyou People's Hospital Affiliated to Soochow University, Yangzhou, Jiangsu, China,
J Cancer Res Clin Oncol. 2015 Oct;141(10):1799-807. doi: 10.1007/s00432-014-1870-5. Epub 2014 Nov 12.
The aim of this study was to perform a meta-analysis to summarize the available evidence from prospective studies on the association between height and kidney cancer risk.
Relevant studies were identified through the MEDLINE and EMBASE databases up to July 2014, as well as through the references from the retrieved articles. Relative risks (RRs) from individual studies were pooled by using a random-effects model.
A total of fourteen prospective studies of adult height and kidney cancer risk with 18,766 cases were included in the meta-analysis. Overall, per 10-cm increase in height was associated with an increased risk of kidney cancer (RR 1.23; 95 % confidence interval 1.18-1.28, I(2) = 11.8 %). Subgroup analysis showed a basically consistent result with the overall analysis. There was no evidence of publication bias.
High adult height was positively associated with the risk of kidney cancer in both men and women in this meta-analysis. Future prospective studies are needed to determine the generalizability of these findings to non-Caucasians.
本研究旨在进行一项荟萃分析，以总结前瞻性研究中关于身高与肾癌风险之间关联的现有证据。
通过检索截至2014年7月的MEDLINE和EMBASE数据库以及检索到的文章的参考文献来确定相关研究。使用随机效应模型汇总各研究的相对风险（RR）。
该荟萃分析共纳入了14项关于成人身高与肾癌风险的前瞻性研究，涉及18766例病例。总体而言，身高每增加10厘米，肾癌风险增加（RR 1.23；95%置信区间1.18 - 1.28，I² = 11.8%）。亚组分析结果与总体分析基本一致。没有证据表明存在发表偏倚。
在此荟萃分析中，成人身高较高与男性和女性的肾癌风险均呈正相关。未来需要进行前瞻性研究以确定这些发现对非白种人的普遍性。
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