Wang Fang, Xu Xingxiang, Yang Junjun, Min Lingfeng, Liang Sudong, Chen Yong
Department of Respiration, Clinical Medical School of Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, China.
Department of Urology, Taizhou People's Hospital of Jiangsu Province, Taizhou, Jiangsu, China.
PLoS One. 2017 Sep 26;12(9):e0185316. doi: 10.1371/journal.pone.0185316. eCollection 2017.
The association between height and lung cancer risk has been investigated by epidemiological studies but the results are inconsistent. This meta-analysis was to evaluate whether the height is associated with lung cancer.
We identified relevant articles by searching the MEDLINE and EMBASE databases, and reviewed the reference lists of selected papers. A random effect model was used to calculate summary odds ratios (OR) and relative risk (RR) with 95% confidence intervals (95% CI). Publication bias was estimated using Egger's regression asymmetry test.
We included a total 16 studies (15 prospective studies and one case-control study) on adult height and lung cancer risk in the meta-analysis. Overall, per 10-cm height increases were associated with increased risk of lung cancer (RR 1.06; 95% CI 1.03-1.09, I2 = 43.6%).
In this meta-analysis, high adult height is related to increased lung cancer risk. Well-designed, large prospective studies are required to obtain a better indication of the relationship.
流行病学研究已对身高与肺癌风险之间的关联进行了调查，但结果并不一致。本荟萃分析旨在评估身高是否与肺癌有关。
我们通过检索MEDLINE和EMBASE数据库来识别相关文章，并查阅所选论文的参考文献列表。采用随机效应模型计算汇总比值比（OR）和相对风险（RR）以及95%置信区间（95%CI）。使用Egger回归不对称检验评估发表偏倚。
在本荟萃分析中，我们总共纳入了16项关于成人身高与肺癌风险的研究（15项前瞻性研究和1项病例对照研究）。总体而言，身高每增加10厘米，肺癌风险增加（RR 1.06；95%CI 1.03 - 1.09，I² = 43.6%）。
在本荟萃分析中，成人身高较高与肺癌风险增加有关。需要设计良好的大型前瞻性研究来更好地表明这种关系。
