阿柏西普注射后眼内炎症的频率及特征
Frequency and characteristics of intraocular inflammation after aflibercept injection.
作者信息
Fine Howard F, Roth Daniel B, Shah Sumit P, Haque Tahia, Wheatley H Matthew
机构信息
Department of Ophthalmology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
出版信息
Retina. 2015 Apr;35(4):681-6. doi: 10.1097/IAE.0000000000000398.
PURPOSE
To report the frequency and characteristics of intraocular inflammation after intravitreal aflibercept injection.
METHODS
A single-center retrospective study was performed in patients who received intravitreal aflibercept from November 2011 through June 2013.
RESULTS
There were 28 cases of intraocular inflammation after a total of 5,905 aflibercept injections among 1,660 patients. The mean baseline acuity was 20/57, which decreased to 20/179 at diagnosis (P < 0.0001) but recovered to 20/59 at Month 1, 20/57 at Month 3, and 20/52 at Month 6 (P = not significant). Vitreous culture and injection of antibiotics were performed in eight cases, and all were culture negative; the remainder received only topical corticosteroids.
CONCLUSION
The frequency of inflammation after aflibercept was 0.47% per injection. Visual acuity and inflammation returned to baseline within 1 month in most cases with topical corticosteroid treatment.
目的
报告玻璃体内注射阿柏西普后眼内炎症的发生率及特征。
方法
对2011年11月至2013年6月期间接受玻璃体内注射阿柏西普的患者进行单中心回顾性研究。
结果
1660例患者共接受5905次阿柏西普注射，其中发生28例眼内炎症。基线平均视力为20/57，诊断时降至20/179（P<0.0001），但在第1个月恢复至20/59，第3个月为20/57，第6个月为20/52（P无统计学意义）。8例患者进行了玻璃体培养并注射抗生素，所有培养结果均为阴性；其余患者仅接受局部皮质类固醇治疗。
结论
阿柏西普注射后炎症发生率为每次注射0.47%。在大多数接受局部皮质类固醇治疗的病例中，视力和炎症在1个月内恢复至基线水平。
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