Gopal K V T, Rao G Raghurama, Kumar Y Harikishan
Department of Dermatology, Maharajah's Institute of Medical Sciences, Nellimarla, Vizianagaram District, Andhra Pradesh, India.
Department of Dermatology, Surya Skin Care and Research Center, Visakhapatnam, Andhra Pradesh, India.
Indian Dermatol Online J. 2014 Oct;5(4):456-60. doi: 10.4103/2229-5178.142493.
Though it is well-known that vitiligo is associated with other autoimmune disorders, few Indian studies have focused on the relation between vitiligo, autoimmune thyroid dysfunction and diabetes mellitus.
This case-control study included 150 new cases of vitiligo and 100 age and sex-matched controls. A complete history and thorough dermatological examination was done. Serum samples from both patients and controls were collected and assayed for triiodothyronine, thyroxine, thyroid-stimulating hormone, anti-thyroid antibodies-anti-thyroid peroxidase and anti-thyroglobulin and fasting plasma glucose.
Thyroid hormonal profile revealed autoimmune thyroid dysfunction manifesting as hypothyroidism in 30 (20%) vitiligo patients and two controls (2%). Diabetes mellitus was present in 24 (16%) vitiligo patients and five controls. Seven (4.7%) patients had both hypothyroidism and diabetes mellitus.
There is a clear association between vitiligo, autoimmune hypothyroidism and diabetes mellitus. It would be very useful to screen for thyroid dysfunction and diabetes mellitus in all patients with vitiligo.
尽管众所周知白癜风与其他自身免疫性疾病有关，但印度很少有研究关注白癜风、自身免疫性甲状腺功能障碍和糖尿病之间的关系。
这项病例对照研究纳入了150例新发白癜风患者和100例年龄及性别匹配的对照。进行了完整的病史采集和全面的皮肤科检查。收集患者和对照的血清样本，检测三碘甲状腺原氨酸、甲状腺素、促甲状腺激素、抗甲状腺抗体——抗甲状腺过氧化物酶和抗甲状腺球蛋白以及空腹血糖。
甲状腺激素谱显示，30例（20%）白癜风患者和2例对照（2%）存在表现为甲状腺功能减退的自身免疫性甲状腺功能障碍。24例（16%）白癜风患者和5例对照患有糖尿病。7例（4.7%）患者同时患有甲状腺功能减退和糖尿病。
白癜风、自身免疫性甲状腺功能减退和糖尿病之间存在明显关联。对所有白癜风患者进行甲状腺功能障碍和糖尿病筛查将非常有用。
