Shetty Ramith P, Fernandes Michelle, Sukumar D, Shivshankara A R, Jayaraman Jyothi, Martis Jacintha, Bhat Ramesha, Dsouza Myfanwy, Monteiro Rochelle
Department of Dermatology, Father Muller Medical College, Mangalore, India.
Department of Dermatology, A J Institute of Medical Sciences, Mangalore, India.
Arch Dermatol Res. 2025 Jan 9;317(1):217. doi: 10.1007/s00403-024-03765-9.
Vitiligo is a depigmenting disorder characterized by melanocyte loss, which results in pigment dilution of the skin. Vitiligo is commonly associated with thyroid disorders and thyroid stimulating hormone (TSH) is a sensitive marker to detect thyroid disorders. S100B is damage associated molecular pattern (DAMP) molecule released when there is melanocyte damage. In this study, we are estimating the serum TSH and S100B levels in vitiligo patients and controls and correlating them with disease activity. A cross-sectional study was conducted on 39 cases of vitiligo and controls. Demographic details were collected, the cases were examined and Vitiligo European Task Force (VETF) scoring was performed. Serum S100B was analyzed using an ELISA kit and serum TSH levels were estimated. Age of the participants ranged from 14 to 81 years with a mean and standard deviation of 44.08 ± 16.078 years. Female preponderance was noted. Vitiligo vulgaris was the most common presentation. Serum TSH (p = 0.32) and S100B (p = 0.22) levels between cases and controls were not statistically significant. Serum S100B level had a weak positive correlation with the spreading component of VETF score and it was statistically significant (p = 0.004). Mucosal vitiligo had higher levels of serum S100B levels compared to other types of vitiligo. In our study both serum TSH and S100B levels have demonstrated limited utility in distinguishing between vitiligo patients and controls. S100B showed a weak correlation with VETF scores indicating its potential (though limited) as a disease activity marker. Therefore, the potential of using this as a biomarker is debatable, and further multicentric studies with a larger sample size are required to establish the correlation.
白癜风是一种以黑素细胞缺失为特征的色素脱失性疾病，可导致皮肤色素稀释。白癜风通常与甲状腺疾病相关，促甲状腺激素（TSH）是检测甲状腺疾病的敏感标志物。S100B是黑素细胞受损时释放的损伤相关分子模式（DAMP）分子。在本研究中，我们评估了白癜风患者和对照组的血清TSH和S100B水平，并将它们与疾病活动度相关联。对39例白癜风患者和对照组进行了一项横断面研究。收集了人口统计学细节，对病例进行了检查并进行了白癜风欧洲工作组（VETF）评分。使用酶联免疫吸附测定（ELISA）试剂盒分析血清S100B，并评估血清TSH水平。参与者的年龄范围为14至81岁，平均年龄和标准差为44.08±16.078岁。女性占优势。寻常型白癜风是最常见的表现形式。病例组和对照组之间的血清TSH水平（p = 0.32）和S100B水平（p = 0.22）无统计学意义。血清S100B水平与VETF评分的扩散成分呈弱正相关，且具有统计学意义（p = 0.004）。与其他类型的白癜风相比，黏膜型白癜风的血清S100B水平更高。在我们的研究中，血清TSH和S100B水平在区分白癜风患者和对照组方面均显示出有限的效用。S100B与VETF评分呈弱相关，表明其作为疾病活动标志物的潜力（尽管有限）。因此，将其用作生物标志物的潜力存在争议，需要进一步开展更大样本量的多中心研究来确定这种相关性。
