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超越细胞发现的时代。

Beyond the age of cellular discovery.

机构信息

Department of Cancer Biology and the Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

出版信息

Nat Immunol. 2014 Dec;15(12):1095-7. doi: 10.1038/ni.3034.

DOI:10.1038/ni.3034
PMID:25396342
Abstract

The combination of machine-learning tools and mass-cytometry measurements of more than 30 protein markers per cell comprehensively maps cell identity in the heterogeneous myeloid cell system and reveals the global effect of deletion of the gene encoding the receptor for the growth factor GM-CSF.

摘要

机器学习工具与单细胞内 30 多种蛋白标志物的质谱流式细胞术测量相结合,全面绘制了异质性髓系细胞系统中的细胞特征图谱,并揭示了生长因子 GM-CSF 受体基因缺失对其的全局影响。

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本文引用的文献

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High-dimensional analysis of the murine myeloid cell system.对鼠类髓系细胞系统的高维分析。
Nat Immunol. 2014 Dec;15(12):1181-9. doi: 10.1038/ni.3006. Epub 2014 Oct 12.
2
Macrophage activation and polarization: nomenclature and experimental guidelines.巨噬细胞激活与极化:命名及实验指南
Immunity. 2014 Jul 17;41(1):14-20. doi: 10.1016/j.immuni.2014.06.008.
3
Automated identification of stratifying signatures in cellular subpopulations.细胞亚群分层特征的自动识别。
Am J Respir Crit Care Med. 2022 Jan 1;205(1):46-59. doi: 10.1164/rccm.202104-1027OC.
4
Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy.无监督机器学习揭示了 COVID-19、鼻病毒感染和癌症治疗中的关键免疫细胞亚群。
Elife. 2021 Aug 5;10:e64653. doi: 10.7554/eLife.64653.
5
Machine Learning Techniques for Soybean Charcoal Rot Disease Prediction.用于大豆炭腐病预测的机器学习技术
Front Plant Sci. 2020 Dec 14;11:590529. doi: 10.3389/fpls.2020.590529. eCollection 2020.
6
Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy.无监督机器学习揭示了新冠病毒感染、鼻病毒感染和癌症治疗中的关键免疫细胞亚群。
bioRxiv. 2020 Nov 4:2020.07.31.190454. doi: 10.1101/2020.07.31.190454.
7
Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells.无监督机器学习揭示胶质母细胞瘤肿瘤细胞的风险分层。
Elife. 2020 Jun 23;9:e56879. doi: 10.7554/eLife.56879.
8
From Bivariate to Multivariate Analysis of Cytometric Data: Overview of Computational Methods and Their Application in Vaccination Studies.从细胞计数数据的双变量分析到多变量分析:计算方法概述及其在疫苗接种研究中的应用
Vaccines (Basel). 2020 Mar 20;8(1):138. doi: 10.3390/vaccines8010138.
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Single-cell technologies in reproductive immunology.生殖免疫领域的单细胞技术。
Am J Reprod Immunol. 2019 Sep;82(3):e13157. doi: 10.1111/aji.13157. Epub 2019 Jun 26.
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Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types.计算免疫监测揭示异常双阴性 T 细胞存在于多种人类肿瘤类型中。
Cancer Immunol Res. 2019 Jan;7(1):86-99. doi: 10.1158/2326-6066.CIR-17-0692. Epub 2018 Nov 9.
Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2770-7. doi: 10.1073/pnas.1408792111. Epub 2014 Jun 16.
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Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development.单细胞轨迹检测揭示了人类 B 细胞发育中的进展和调控协调。
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