糖基化加工的抑制改变了由猿猴肉瘤病毒癌基因转化的细胞的生长参数。
Inhibition of glycosylation processing alters the growth parameters of cells transformed by the oncogene of simian sarcoma virus.
作者信息
Hadwiger-Fangmeier A, Niemann H, Tamura T
机构信息
Institut für Medizinische Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.
出版信息
Arch Virol. 1989;104(3-4):339-45. doi: 10.1007/BF01315555.
PMID:2539799
Abstract
Normal rat kidney (NRK) cells transformed by the v-sis oncogene of simian sarcoma virus (SSV) were treated with the glucosidase I inhibitor castanospermine. The inhibitor did not change cell morphology, but specific growth parameters such as serum- and anchorage-independence were lost.
摘要
用来自猿猴肉瘤病毒（SSV）的v-sis癌基因转化的正常大鼠肾（NRK）细胞，用葡糖苷酶I抑制剂栗精胺进行处理。该抑制剂没有改变细胞形态，但诸如血清非依赖性和锚定非依赖性等特定生长参数丧失了。
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