Lippmann M
New York University Medical Center, Institute of Environmental Medicine, Tuxedo 10987.
Environ Health Perspect. 1989 Feb;79:203-5. doi: 10.1289/ehp.8979203.
Research on human exposure to acidic aerosols and the health effects of such exposures has substantially strengthened the hypothesis that such aerosols are a causal factor for excesses in human mortality and morbidity that have been previously associated with crude exposure indices such as British Smoke, total suspended particulate matter, and sulfur dioxide. Research reported at this symposium also showed that combined exposures to acid aerosols and other ubiquitous air pollutants such as O3, NO2, HNO3, and SO2 produce greater effects in both humans and animals than exposures to each agent separately. The responses reported ranged from physiological functions to lung structure. Furthermore, some of the effects were cumulative with increasing duration of daily exposure and number of repetitive exposures. Critical areas for further research include better definition of the critical temporal parameters affecting exposure and response, effects of mixed pollutant exposures, and pathogenetic mechanisms for acid aerosol-induced chronic lung damage.
关于人类接触酸性气溶胶及其健康影响的研究，极大地强化了这样一种假说：此类气溶胶是导致人类死亡率和发病率过高的一个因果因素，而此前这些过高的死亡率和发病率一直与诸如英国烟雾、总悬浮颗粒物和二氧化硫等粗略的暴露指数相关联。本次研讨会上报告的研究还表明，与单独接触每种污染物相比，同时接触酸性气溶胶和其他普遍存在的空气污染物（如臭氧、二氧化氮、硝酸和二氧化硫）对人类和动物产生的影响更大。报告的反应范围从生理功能到肺部结构。此外，一些影响会随着每日暴露时间的延长和重复暴露次数的增加而累积。进一步研究的关键领域包括更明确地界定影响暴露和反应的关键时间参数、混合污染物暴露的影响，以及酸性气溶胶诱发慢性肺损伤的发病机制。
